In vitro models of pancreatic cancer for translational oncology research.
In vitro models of pancreatic cancer for translational oncology research.
复制标题
DOI：
10.1517/17460440902821657
复制
发表时间：
2009-04-01
影响因子：
6.3
通讯作者：
Maitra A
中科院分区：
文献类型：
--
作者：
Feldmann G;Rauenzahn S;Maitra A
胰腺癌是一种死亡率几乎一致的疾病，绝大多数患者在诊断后几个月内死于晚期恶性肿瘤。尽管我们对胰腺癌发生的分子机制的理解有了相当大的进展，但这些知识尚未完全转化为临床可用的治疗策略，从而显着改善无病生存率或总生存率。基于细胞系的体外模型系统提供了强有力的工具来鉴定用于治疗干预的潜在分子靶点以及用于新药候选物的初始临床前评价。在这里，我们提供了一个简短的概述，最近的文献对胰腺癌的细胞系为基础的模型系统和他们的应用在寻找新的治疗方法对这种恶性疾病。虽然胰腺癌的体外模型对于遗传研究和药物发现中的初始功能筛选具有巨大价值，但它们具有几个迫切的缺点，并且通常在预测人类的治疗反应方面很差。因此，在大多数情况下，它们被成功地利用来产生假设并鉴定新疗法的分子靶标，随后使用更先进的体内模型系统和临床试验对其进行进一步深入表征。
Pancreatic cancer is a disease of near uniform fatality and the overwhelming majority of patients succumb to their advanced malignancy within a few months of diagnosis. Despite considerable advances in our understanding of molecular mechanisms underlying pancreatic carcinogenesis, this knowledge has not yet been fully translated into clinically available treatment strategies that yield significant improvements in disease free or overall survival. Cell line-based in vitro model systems provide powerful tools to identify potential molecular targets for therapeutic intervention as well as for initial pre-clinical evaluation of novel drug candidates. Here we provide a brief overview of recent literature on cell line-based model systems of pancreatic cancer and their application in the search for novel therapeutics against this vicious disease. While in vitro models of pancreatic cancer are of tremendous value for genetic studies and initial functional screenings in drug discovery, they carry several imanent drawbacks and are often poor in predicting therapeutic response in humans. Therefore, in most instances they are successfully exploited to generate hypothesis and identify molecular targets for novel therapeutics, which are subsequently subject to further in-depth characterization using more advanced in vivo model systems and clinical trials.
登录
查看更多内容
影响因子：
56.9
作者：
Berman, DM;Karhadkar, SS;Beachy, PA
通讯作者：
Beachy, PA
DOI：
10.1007/bf02890431
发表时间：
1992-02-01
期刊：
VIRCHOWS ARCHIV B-CELL PATHOLOGY INCLUDING MOLECULAR PATHOLOGY
影响因子：
--
作者：
ELSASSER, HP;LEHR, U;KERN, HF
通讯作者：
KERN, HF
影响因子：
5.8
作者：
Burris, Howard, III;Rocha-Lima, Caio
通讯作者：
Rocha-Lima, Caio
影响因子：
24.5
作者：
Feldmann, G.;Habbe, N.;Maitra, A.
通讯作者：
Maitra, A.
影响因子：
29.4
作者：
Erkan, Mert;Kleeff, Joerg;Friess, Helmut
通讯作者：
Friess, Helmut