Survivin expression in oral squamous cell carcinoma.
Survivin expression in oral squamous cell carcinoma.
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DOI：
10.1038/sj.bjc.6601402
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发表时间：
2003-12-15
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
应用免疫组化和Western blotting方法检测了110例口腔鳞状细胞癌（SCC）、6例淋巴结转移灶和1例远处转移灶中Survivin的表达。总的来说，91例（82.7%）癌和所有转移（7例，100%）的生存素表达阳性，加权生存素评分范围为1至4。相反，正常口腔上皮细胞不表达生存素。Survivin的表达与年龄、性别、肿瘤大小、有无淋巴结转移及远处转移无明显相关性。Survivin表达在低分化肿瘤中增加，即使差异没有统计学意义。相比之下，当分析预后意义时，低生存素表达的患者的生存率明显高于高生存素表达组（P<0.05）。这些数据表明，生存素的表达可能会识别口腔鳞状细胞癌的情况下，更具侵略性和侵袭性的表型。
A series of 110 cases of oral squamous cell carcinoma (SCC) together with six lymph node and one distant metastatic lesions was analysed for expression of survivin, a recent apoptosis inhibitor, by immunohistochemistry and Western blotting. In total, 91 cases (82.7%) of carcinoma and all metastasis (seven cases, 100%) were positive for survivin expression, with weighted survivin scores ranging from 1 to 4. In contrast, normal oral epithelium did not express survivin. There was no significant correlation between survivin expression and age, sex, tumour size, the presence of lymph node and distant metastases. Survivin expression was increased in poorly differentiated tumours, even if differences were not statistically significant. In contrast, when analysed for prognostic significance, patients with low survivin expression had statistically significant better survival rates than the group with high survivin expression (P<0.05). These data suggest that survivin expression may identify cases of oral SCC with more aggressive and invasive phenotype.
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影响因子：
9.7
作者：
Glinsky, GV;Glinsky, VV;Hueser, CJ
通讯作者：
Hueser, CJ
影响因子：
9.2
作者：
Fraser, AG;James, C;Hengartner, MO
通讯作者：
Hengartner, MO
影响因子：
3.6
作者：
Lo Muzio, L;Staibano, S;Altieri, DC
通讯作者：
Altieri, DC
影响因子：
11.4
作者：
Deveraux, QL;Roy, N;Reed, JC
通讯作者：
Reed, JC
影响因子：
82.9
作者：
Ambrosini, G;Adida, C;Altieri, DC
通讯作者：
Altieri, DC