A key role for neuropeptide Y in lifespan extension and cancer suppression via dietary restriction.
A key role for neuropeptide Y in lifespan extension and cancer suppression via dietary restriction.
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DOI：
10.1038/srep04517
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发表时间：
2014-03-31
影响因子：
4.6
通讯作者：
Shimokawa I
中科院分区：
文献类型：
--
作者：
Chiba T;Tamashiro Y;Park D;Kusudo T;Fujie R;Komatsu T;Kim SE;Park S;Hayashi H;Mori R;Yamashita H;Chung HY;Shimokawa I
对哺乳动物饮食限制延长寿命所必需的基因的了解尚不完整。在这项研究中，我们发现神经肽Y （Npy）介导能量不足的生理适应，是小鼠DR和长寿之间的重要联系。与野生型小鼠相比，npy缺失小鼠终身30% DR的延长寿命作用减弱，对自发肿瘤发生和氧化应激反应的影响也减弱。相反，在适应DR过程中激活的生理过程，包括合成代谢信号分子（胰岛素和胰岛素样生长因子-1）的抑制，脂肪因子和皮质酮水平的调节，以及优先的脂肪酸氧化，都不受Npy缺失的影响。这些结果表明，Npy在介导DR的作用中起着关键作用。我们还提供证据表明，大多数对DR的生理适应可以在没有Npy的小鼠中实现。
Knowledge of genes essential for the life-extending effect of dietary restriction (DR) in mammals is incomplete. In this study, we found that neuropeptide Y (Npy), which mediates physiological adaptations to energy deficits, is an essential link between DR and longevity in mice. The lifespan-prolonging effect of lifelong 30% DR was attenuated in Npy-null mice, as was the effect on the occurrence of spontaneous tumors and oxidative stress responses in comparison to wild-type mice. In contrast, the physiological processes activated during adaptation to DR, including inhibition of anabolic signaling molecules (insulin and insulin-like growth factor-1), modulation of adipokine and corticosterone levels, and preferential fatty acid oxidation, were unaffected by the absence of Npy. These results suggest a key role for Npy in mediating the effects of DR. We also provide evidence that most of the physiological adaptations to DR could be achieved in mice without Npy.
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影响因子：
4.1
作者：
Chiba, Takuya;Komatsu, Toshimitsu;Shimokawa, Isao
通讯作者：
Shimokawa, Isao
DOI：
10.1126/science.1173635
发表时间：
2009-07-10
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Colman RJ;Anderson RM;Johnson SC;Kastman EK;Kosmatka KJ;Beasley TM;Allison DB;Cruzen C;Simmons HA;Kemnitz JW;Weindruch R
通讯作者：
Weindruch R
影响因子：
64.8
作者：
Mattison, Julie A.;Roth, George S.;Beasley, T. Mark;Tilmont, Edward M.;Handy, April M.;Herbert, Richard L.;Longo, Dan L.;Allison, David B.;Young, Jennifer E.;Bryant, Mark;Barnard, Dennis;Ward, Walter F.;Qi, Wenbo;Ingram, Donald K.;de Cabo, Rafael
通讯作者：
de Cabo, Rafael
DOI：
10.1152/ajpendo.00009.2005
发表时间：
2005-10-01
影响因子：
5.1
作者：
Granneman, JG;Li, PP;Lu, YY
通讯作者：
Lu, YY
影响因子：
9.2
作者：
Kapahi, P;Zid, BM;Benzer, S
通讯作者：
Benzer, S