Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study.
Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study.
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DOI：
10.1038/nature11432
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发表时间：
2012-09-13
期刊：
影响因子：
64.8
通讯作者：
de Cabo, Rafael
中科院分区：
文献类型：
--
作者：
Mattison, Julie A.;Roth, George S.;Beasley, T. Mark;Tilmont, Edward M.;Handy, April M.;Herbert, Richard L.;Longo, Dan L.;Allison, David B.;Young, Jennifer E.;Bryant, Mark;Barnard, Dennis;Ward, Walter F.;Qi, Wenbo;Ingram, Donald K.;de Cabo, Rafael
通过热量限制（CR）延长寿命已在多种物种中得到广泛报道，并且仍然处于抗衰老干预研究的前沿。我们根据美国国家老龄化研究所 (NIA) 对恒河猴进行的一项为期 23 年的研究报告了 CR 的健康寿命和生存影响。相对于对照组，在较大年龄开始 CR 并没有增加生存率；然而，CR 猴表现出改善的代谢特征，并且血浆异前列烷水平表明氧化应激可能较少。当在幼猴中开始治疗时，CR 猴中出现与年龄相关的疾病发作延迟的趋势（p=0.06）；但与文献报道的另一项研究相比，生存曲线并没有得到改善。这表明 CR 对长寿动物的影响是复杂的，并且可能取决于各种环境、营养和遗传因素。
Life extension by calorie restriction (CR) has been widely reported in a variety of species and remains on the forefront of anti-aging intervention studies. We report healthspan and survival effects of CR from a 23-year study in rhesus macaques conducted at the National Institute on Aging (NIA). CR initiated at older ages did not increase survival relative to Controls; however, CR monkeys demonstrated an improved metabolic profile and may have less oxidative stress as indicated by plasma isoprostane levels. When initiated in young monkeys, there was a trend (p=0.06) for a delay in age-associated disease onset in CR monkeys; but again, survival curves were not improved, in contrast to another study reported in the literature. This suggests that the effects of CR in a long-lived animal are complex and likely dependent on a variety of environmental, nutritional, and genetic factors.
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影响因子：
9.8
作者：
Roncal-Jimenez, Carlos A.;Lanaspa, Miguel A.;Rivard, Christopher J.;Nakagawa, Takahiko;Gabriela Sanchez-Lozada, L.;Jalal, Diana;Andres-Hernando, Ana;Tanabe, Katsuyuki;Madero, Magdalena;Li, Nanxing;Cicerchi, Christina;Mc Fann, Kim;Sautin, Yuri Y.;Johnson, Richard J.
通讯作者：
Johnson, Richard J.
DOI：
10.1126/science.1173635
发表时间：
2009-07-10
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Colman RJ;Anderson RM;Johnson SC;Kastman EK;Kosmatka KJ;Beasley TM;Allison DB;Cruzen C;Simmons HA;Kemnitz JW;Weindruch R
通讯作者：
Weindruch R
影响因子：
--
作者：
Lomba, A.;Milagro, F. I.;Martinez, J. A.
通讯作者：
Martinez, J. A.
影响因子：
7.8
作者：
Harper, James M.;Leathers, Charles W.;Austad, Steven N.
通讯作者：
Austad, Steven N.
影响因子：
4.8
作者：
Forster, MJ;Morris, P;Sohal, RS
通讯作者：
Sohal, RS