Local mechanical properties of white matter structures in the human brain.
Local mechanical properties of white matter structures in the human brain.
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DOI：
10.1016/j.neuroimage.2013.04.089
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发表时间：
2013-10-01
期刊：
影响因子：
5.7
通讯作者：
Georgiadis, John G.
中科院分区：
文献类型：
--
作者：
Johnson, Curtis L.;McGarry, Matthew D. J.;Gharibans, Armen A.;Weaver, John B.;Paulsen, Keith D.;Wang, Huan;Olivero, William C.;Sutton, Bradley P.;Georgiadis, John G.
利用磁共振弹性成像(MRE)无创测量脑组织的力学特性，已成为研究神经疾病的一种有前途的方法。到目前为止，脑MRE的研究仅限于报告全局机械特性，尽管对白质结构中特定结构的刚性进行量化可能对评估疾病的局部影响有价值。本文报道了用MRE和基于图谱的分割技术测量健康志愿者的胼胝体和放射冠的力学特性。这两种结构都被发现比整个白质要僵硬得多，与放射冠相比，胼胝体表现出更大的僵硬和更少的粘性阻尼。通过重复实验对局部测量和全局测量的可靠性进行了评估，各测量的变异系数均小于10%。通过对轴突微结构的弥散张量成像的测量，显示了胼胝体和放射状冠内的力学特性之间的相关性。
The noninvasive measurement of the mechanical properties of brain tissue using magnetic resonance elastography (MRE) has emerged as a promising method for investigating neurological disorders. To date, brain MRE investigations have been limited to reporting global mechanical properties, though quantification of the stiffness of specific structures in the white matter architecture may be valuable in assessing the localized effects of disease. This paper reports the mechanical properties of the corpus callosum and corona radiata measured in healthy volunteers using MRE and atlas-based segmentation. Both structures were found to be significantly stiffer than overall white matter, with the corpus callosum exhibiting greater stiffness and less viscous damping than the corona radiata. Reliability of both local and global measures was assessed through repeated experiments, and the coefficient of variation for each measure was less than 10%. Mechanical properties within the corpus callosum and corona radiata demonstrated correlations with measures from diffusion tensor imaging pertaining to axonal microstructure.
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影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
通过磁共振弹性成像确定阿尔茨海默氏病的大脑硬度降低。
影响因子：
4.4
作者：
Murphy, Matthew C.;Huston, John, III;Jack, Clifford R., Jr.;Glaser, Kevin J.;Manduca, Armando;Felmlee, Joel P.;Ehman, Richard L.
通讯作者：
Ehman, Richard L.
影响因子：
2.4
作者：
Arbogast, KB;Margulies, SS
通讯作者：
Margulies, SS
影响因子：
2.5
作者：
LAMANTIA, AS;RAKIC, P
通讯作者：
RAKIC, P
影响因子：
3.5
作者：
McGarry MD;Van Houten EE;Perriñez PR;Pattison AJ;Weaver JB;Paulsen KD
通讯作者：
Paulsen KD