Decreased brain stiffness in Alzheimer's disease determined by magnetic resonance elastography.
Decreased brain stiffness in Alzheimer's disease determined by magnetic resonance elastography.
复制标题
通过磁共振弹性成像确定阿尔茨海默氏病的大脑硬度降低。
DOI：
10.1002/jmri.22707
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发表时间：
2011-09
影响因子：
4.4
通讯作者：
Ehman, Richard L.
中科院分区：
文献类型：
--
作者：
Murphy, Matthew C.;Huston, John, III;Jack, Clifford R., Jr.;Glaser, Kevin J.;Manduca, Armando;Felmlee, Joel P.;Ehman, Richard L.
为了测试患者对使用软振源进行3D MRE脑检查的接受度和重复性，并确定MRE是否可以非侵入性地测量阿尔茨海默病(AD)引起的脑实质弹性特性的变化。使用加速自旋回波EPI脉冲序列进行MRE检查，并使用3D直接反转算法计算硬度。在10名男性志愿者中对该技术的重复性进行了评估，他们每人都接受了分成两次成像的4次MRE检查。28名志愿者，7名可能患有AD的患者，14名年龄和性别匹配的PIB阴性(匹兹堡化合物B，一种PET淀粉样蛋白成像配体)认知正常对照(CN-)，以及7名年龄和性别匹配的PIB阳性认知正常对照(CN+)，评估了阿尔茨海默病对大脑僵硬的影响。10名志愿者的僵硬中位数为3.07 kpa，范围为0.40 kpa。这些志愿者的中位数和最大变异系数分别为1.71%和3.07%。14名CN-受试者的僵硬中位数为2.37 kPa(0.44 kpa范围)，而CN+组为2.32 kpa(0.49 kpa范围)，AD组为2.20 kpa(0.33 kpa范围)。3组间差异有统计学意义(P=0.0055，Kruskal-Wallis单向方差分析)。CN+和CN-组与AD组比较差异均有统计学意义。脑部3DMRE可重复进行，显示AD患者脑组织僵硬程度显著降低。
To test patient acceptance and reproducibility of the 3D MRE brain exam using a soft vibration source, and to determine if MRE could noninvasively measure a change in the elastic properties of the brain parenchyma due to Alzheimer's disease (AD). MRE exams were performed using an accelerated spin-echo EPI pulse sequence and stiffness was calculated with a 3D direct inversion algorithm. Reproducibility of the technique was assessed in 10 male volunteers, who each underwent 4 MRE exams separated into 2 imaging sessions. The effect of Alzheimer's disease on brain stiffness was assessed in 28 volunteers, 7 with probable AD, 14 age- and gender-matched PIB-negative (Pittsburgh Compound B, a PET amyloid imaging ligand) cognitively normal controls (CN-), and 7 age- and gender-matched PIB-positive cognitively normal controls (CN+). The median stiffness of the 10 volunteers was 3.07 kPa with a range of 0.40 kPa. The median and maximum coefficients of variation for these volunteers were 1.71% and 3.07%. The median stiffness of the 14 CN- subjects was 2.37 kPa (0.44 kPa range) compared to 2.32 kPa (0.49 kPa range) within the CN+ group and 2.20 kPa (0.33 kPa range) within the AD group. A significant difference was found between the 3 groups (p=0.0055, Kruskal-Wallis one-way analysis of variance). Both the CN+ and CN- groups were significantly different from the AD group. 3D MRE of the brain can be performed reproducibly and demonstrates significantly reduced brain tissue stiffness in patients with AD.
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影响因子：
4.2
作者：
Salat, D. H.;Tuch, D. S.;van der Kouwe, A. J. W.;Greve, D. N.;Pappu, V.;Lee, S. Y.;Hevelone, N. D.;Zaleta, A. K.;Growdon, J. H.;Corkin, S.;Fischl, B.;Rosas, H. D.
通讯作者：
Rosas, H. D.
影响因子：
12.6
作者：
Yin, Meng;Talwalkar, Jayant A.;Ehman, Richard L.
通讯作者：
Ehman, Richard L.
影响因子：
2.9
作者：
Sack, Ingolf;Beierbach, Bernd;Braun, Juergen
通讯作者：
Braun, Juergen
影响因子：
56.9
作者：
MUTHUPILLAI, R;LOMAS, DJ;EHMAN, RL
通讯作者：
EHMAN, RL
影响因子：
11.2
作者：
Klunk, WE;Engler, H;Långström, B
通讯作者：
Långström, B