Intestinal protozoa in hospitalized under-five children with diarrhoea in Nampula - a cross-sectional analysis in a low-income setting in northern Mozambique.
Intestinal protozoa in hospitalized under-five children with diarrhoea in Nampula - a cross-sectional analysis in a low-income setting in northern Mozambique.
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DOI：
10.1186/s12879-021-05881-7
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发表时间：
2021-02-23
影响因子：
3.7
通讯作者：
de Deus N
中科院分区：
文献类型：
--
作者：
Bauhofer AFL;Cossa-Moiane ILC;Marques SDA;Guimarães ELAM;Munlela BA;Anapakala EM;Chiláule JJ;Cassocera M;Langa JS;Chissaque A;Sambo JAM;Manhique-Coutinho LV;Bero DM;Kellogg TA;Gonçalves LAP;de Deus N
在莫桑比克，全国各地都有肠道寄生虫感染的报道。然而，腹泻儿童的感染主要集中在莫桑比克南部地区。这项工作旨在确定莫桑比克北部楠普拉中心医院因腹泻住院的五岁以下儿童感染隐孢子虫属、蓝氏贾第鞭毛虫和溶组织内阿米巴的频率和潜在危险因素。 2015 年 3 月至 2018 年 1 月期间，对楠普拉中心医院因腹泻住院的儿童进行了一项横断面医院监测。社会人口统计信息是通过对儿童照顾者进行半结构化访谈获得的。从每个儿童身上采集一份粪便样本，使用免疫酶技术检测来自隐孢子虫属、兰氏芽胞杆菌和溶组织内阿米巴的抗原。通过逻辑回归模型获得粗比值比和调整比值比（置信区间为 95%），以确定与隐孢子虫属感染相关的因素。和G.兰布利亚。我们样本人群的中位年龄和四分位间距为 12 个月 (8-20)。肠道原虫检出率为21.4%（59/276）。隐孢子虫属是最常见的原生动物 (13.9% - 38/274)，其次是 G. Lamplia (9.1% - 25/274) 和 E. histolytica (0.4% - 1/275)。照顾者不识字（p 值 = 0.042）和营养不良（p 值 = 0.011）的儿童更有可能感染隐孢子虫属。 G. Lamplia 在四人以上家庭的儿童中更为常见（p 值 = 0.039）。在一名 11 个月大的儿童中检测到溶组织内阿米巴，并与隐孢子虫共同感染。并且营养不良。隐孢子虫属兰氏贾第鞭毛虫是楠普拉中心医院住院腹泻儿童中最常见的致病性肠道原虫。我们的研究结果强调了探索看护者的教育水平、儿童营养状况对隐孢子虫感染的重要性以及生活条件，即拥挤的家庭对五岁以下儿童感染兰氏隐孢子虫的重要性。
In Mozambique, infection by intestinal parasites is reported all over the country. However, infection in children with diarrhoea is mostly focused in the southern region of Mozambique. This work aims to determine the frequency and potential risk factors for infection by Cryptosporidium spp., Giardia lamblia, and Entamoeba histolytica in children under-five years hospitalized with diarrhoea in Hospital Central de Nampula, northern Mozambique. A cross-sectional hospital-based surveillance was conducted between March 2015 and January 2018 in children admitted with diarrhoea in Hospital Central de Nampula. Sociodemographic information was obtained through semi-structured interviews applied to the children’s caregivers. A single stool sample was collected from each child to detect antigens from Cryptosporidium spp., G. lamblia, and E. histolytica using an immune-enzymatic technique. Crude and adjusted odds ratios (with 95% Confidence Intervals) were obtained by logistic regression models to identify factors associated with infection by Cryptosporidium spp. and G. lamblia. The median age and interquartile intervals of our sample population was 12 months (8–20). Intestinal protozoa were detected in 21.4% (59/276). Cryptosporidium spp. was the most common protozoa (13.9% - 38/274), followed by G. lamblia (9.1% - 25/274) and E. histolytica (0.4% - 1/275). Children with illiterate caregiver’s (p-value = 0.042) and undernourished (p-value = 0.011) were more likely to be infected by Cryptosporidium spp. G. lamblia was more common in children living in households with more than four members (p-value = 0.039). E. histolytica was detected in an eleven month’s child, co-infected with Cryptosporidium spp. and undernourished. Cryptosporidium spp. and Giardia lamblia were the most common pathogenic intestinal protozoa detected in children with diarrhoea hospitalized in the Hospital Central de Nampula. Our findings obtained highlight the importance of exploring the caregiver’s education level, children’s nutritional status for infections with Cryptosporidium spp., and living conditions, namely crowded households for infections with G. lamblia in children younger than five years.
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影响因子：
3.7
作者：
Forson AO;Arthur I;Ayeh-Kumi PF
通讯作者：
Ayeh-Kumi PF
DOI：
10.4269/ajtmh.2006.75.78
发表时间：
2006-07-01
影响因子：
3.3
作者：
Gatei, Wangeci;Wamae, Claire N.;Hart, Charles A.
通讯作者：
Hart, Charles A.
影响因子：
168.9
作者：
Kotloff, Karen L.;Nataro, James P.;Levine, Myron M.
通讯作者：
Levine, Myron M.
DOI：
10.4269/ajtmh.2007.76.522
发表时间：
2007-03-01
影响因子：
3.3
作者：
Mandomando, Inacio M.;Macete, Eusebio V.;Gascon, Joaquim
通讯作者：
Gascon, Joaquim
DOI：
10.1093/cid/cis762
发表时间：
2012-12
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Muhsen K;Levine MM
通讯作者：
Levine MM