Estrogens prevent metabolic dysfunctions induced by circadian disruptions in female mice.
Estrogens prevent metabolic dysfunctions induced by circadian disruptions in female mice.
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雌激素可预防雌性小鼠因昼夜节律紊乱引起的代谢功能障碍。
DOI：
10.1210/en.2014-1922
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发表时间：
2015-03
期刊：
影响因子：
4.8
通讯作者：
Xu, Yong
中科院分区：
文献类型：
--
作者：
Fukuda, Makoto;Sun, Zheng;Tong, Qingchun;Xu, Yong
昼夜节律紊乱已成为导致肥胖和胰岛素抵抗流行的一个重要因素。然而，治疗由昼夜节律中断引起的代谢功能障碍的干预措施是有限的。卵巢激素雌激素对雌性动物具有重要的抗肥胖和抗糖尿病作用，并对日常行为节律有深远的影响。在内源性雌激素不足的雌性小鼠中，时差模式诱导内脏脂肪积累和全身胰岛素抵抗，这与内脏脂肪库中多个昼夜节律基因的表达改变有关。有趣的是，在补充了外源性雌激素的雌性小鼠中，所有这些时差引起的缺陷都被完全挽救了。我们进一步研究了雌激素缺失或替代的雌性小鼠脂肪组织中昼夜节律基因的24小时振荡，发现昼夜节律基因（周期昼夜节律蛋白同源物2）的表达水平在内脏脂肪组织中以雌激素依赖的方式振荡。总之，我们的研究结果表明，雌激素与脂肪组织中的内在生物钟相互作用，防止昼夜节律中断引起的异常脂质积累。
Circadian disruption has become a significant factor contributing to the epidemics of obesity and insulin resistance. However, interventions to treat metabolic dysfunctions induced by circadian disruptions are limited. The ovarian hormone, estrogen, produces important antiobesity and antidiabetic effects in female animals and has profound effects on daily behavioral rhythms. Here, we show that in female mice depleted with endogenous estrogens, a jet-lag paradigm induced visceral fat accumulation and systemic insulin resistance, which were associated with altered expression of multiple circadian genes in the visceral fat depot. Interestingly, all these jet-lag-induced deficits were completely rescued in female mice supplemented with exogenous estrogens. We further examined 24-hour oscillations of circadian genes in adipose tissues in female mice with estrogen depletion or replacement and showed that expression levels of the circadian gene, period circadian protein homolog 2, oscillate in visceral adipose tissue in an estrogen-dependent manner. Together, our results indicate that estrogens interact with the intrinsic circadian clock in adipose tissue and prevent abnormal lipid accumulation caused by circadian disruptions.
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影响因子：
5.2
作者：
Griebel G;Ravinet-Trillou C;Beeské S;Avenet P;Pichat P
通讯作者：
Pichat P
DOI：
10.1073/pnas.0703247104
发表时间：
2007-09-04
影响因子：
11.1
作者：
Woon, Peng Y.;Kaisaki, Pamela J.;Gauguier, Dominique
通讯作者：
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DOI：
10.1073/pnas.0808180106
发表时间：
2009-03-17
影响因子：
11.1
作者：
Scheer, Frank A. J. L.;Hilton, Michael F.;Shea, Steven A.
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Shea, Steven A.
影响因子：
6.1
作者：
P. Björntorp
通讯作者：
P. Björntorp
影响因子：
2.7
作者：
Nakamura, Takahiro J.;Sellix, Michael T.;Kudo, Takashi;Nakao, Nobuhiro;Yoshimura, Takashi;Ebihara, Shizufumi;Colwell, Christopher S.;Block, Gene D.
通讯作者：
Block, Gene D.