Renal blood flow varies during normal activity in conscious unrestrained rats.
Renal blood flow varies during normal activity in conscious unrestrained rats.
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在清醒、不受约束的大鼠的正常活动期间，肾血流量会发生变化。
DOI：
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发表时间：
1992
影响因子：
--
通讯作者：
E. Bullivant
中科院分区：
文献类型：
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作者：
H. Grady;E. Bullivant
在无束缚大鼠中研究了正常日常活动期间肾血流量（RBF）的变化程度及其对肾神经活动的依赖性。在光暗循环的两个阶段（n = 11）期间记录RBF（用脉冲多普勒血流探针测量）和行为模式（用摄像机观察）。当大鼠完全放松并明显入睡（9%时间）时，RBF最高（100%），但在其余时间内显著降低（P <0.01）。当静止但未完全放松时，RBF为最大值的89.7 +/- 0.3%;当警觉和完全静止时，为74.1 +/- 0.8%;当梳理时，为63.7 +/-0.9%。平均每日RBF为最大流量的80%。在将生理盐水输注到肾动脉周围的袖带中期间，通过轻柔处理将RBF降至最大流量的38.4 +/- 0.7%。当输注改为利多卡因（5%）时，利多卡因阻断了肾神经的传递，相似的治疗使同侧RBF降至80.2 +/- 0.7%，双侧输注降至94.7 +/- 0.7%。我们的结论是，RBF变化很大，在不受限制的动物在正常条件下，这种变化主要是由于肾神经活动的变化。
The extent to which renal blood flow (RBF) varied during normal daily activity and its dependence on renal nerve activity were studied in unrestrained rats. RBF (measured with a pulsed Doppler flow probe) and behavior pattern (observed with a video camera) were recorded during both phases of the light-dark cycle (n = 11). RBF was highest (100%) when the rat was fully relaxed and apparently asleep (9% time) but was significantly lower (P less than 0.01) during the remainder of the time. When quiescent but not fully relaxed, RBF was 89.7 +/- 0.3% of the maximum; when alert and completely still, it was 74.1 +/- 0.8%; and when grooming, it was 63.7 +/- 0.9%. Mean daily RBF was 80% of maximum flow. During saline infusion into cuffs around the renal arteries, RBF was reduced to 38.4 +/- 0.7% of maximum flow by gentle handling. When the infusion was changed to Xylocaine (5%), which blocked transmission in the renal nerve, similar treatment reduced RBF to 80.2 +/- 0.7% with ipsilateral and to 94.7 +/- 0.7% with bilateral infusions. We conclude that RBF varies considerably in unrestrained animals under normal conditions and that the variations largely result from changes in renal nerve activity.
间歇喂养对清醒大鼠肾血流动力学的影响。
DOI：
10.1152/ajprenal.1986.250.3.f566
发表时间：
1986
期刊：
The American journal of physiology
影响因子：
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作者：
GehrigJr,JJ;Jamison,RL;Baylis,C;Troy,JL;Brenner,BM;Jamison,RL
通讯作者：
Jamison,RL
双向方差分析中缺失数据。
DOI：
10.1152/ajpregu.1990.258.2.r291
发表时间：
1990
期刊：
The American journal of physiology
影响因子：
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作者：
Slinker,BK;Glantz,SA
通讯作者：
Glantz,SA