Evaluating the association of single-nucleotide polymorphisms with tenofovir exposure in a diverse prospective cohort of women living with HIV.
Evaluating the association of single-nucleotide polymorphisms with tenofovir exposure in a diverse prospective cohort of women living with HIV.
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在不同的艾滋病毒感染者前瞻性队列中评估单核苷酸多态性与替诺福韦暴露的关联。
DOI：
10.1038/tpj.2017.3
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发表时间：
2018-04
期刊：
影响因子：
--
通讯作者：
Aouizerat BE
中科院分区：
文献类型：
--
作者：
Baxi SM;Greenblatt RM;Bacchetti P;Cohen M;DeHovitz JA;Anastos K;Gange SJ;Young MA;Aouizerat BE
较高的替诺福韦（TFV）暴露会增加肾功能下降的风险，但遗传因素对TFV暴露的影响在很大程度上是未知的。我们调查了12个基因的单核苷酸多态性（SNPs，n = 211）是否可能参与TFV暴露。来自妇女机构间HIV研究的参与者（n = 91）在见证剂量后接受了24小时的TFV密集药代动力学采样，并计算了每名参与者的时间-浓度曲线下面积（AUC）。使用阵列基因分型和桑格测序的组合测定SNP。将线性回归模型应用于经数学转换的AUC。认为满足先验阈值P < 0.001的那些SNP与TFV AUC统计学相关。ABCG 2 SNP rs 2231142与TFV AUC相关，罕见等位基因携带者TFV AUC增加1.51倍（95%置信区间：1.26，1.81; P = 1.7 × 10− 5）。我们提供了ABCG 2中rs 2231142 SNP对24 h TFV AUC具有中等强度影响的证据。
Higher exposure to tenofovir (TFV) increases the risk for kidney function decline, but the impact of genetic factors on TFV exposure is largely unknown. We investigated whether single-nucleotide polymorphisms (SNPs, n = 211) in 12 genes are potentially involved in TFV exposure. Participants (n = 91) from the Women’s Interagency HIV Study, underwent a 24 h intensive pharmacokinetic sampling of TFV after witnessed dose and TFV area under the time–concentration curves (AUCs) were calculated for each participant. SNPs were assayed using a combination of array genotyping and Sanger sequencing. Linear regression models were applied to logarithmically transformed AUC. Those SNPs that met an a priori threshold of P < 0.001 were considered statistically associated with TFV AUC. ABCG2 SNP rs2231142 was associated with TFV AUC with rare allele carriers displaying 1.51-fold increase in TFV AUC (95% confidence interval: 1.26, 1.81; P = 1.7 × 10− 5). We present evidence of a moderately strong effect of the rs2231142 SNP in ABCG2 on a 24 h TFV AUC.
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DOI：
10.1097/qad.0000000000000033
发表时间：
2014-01-02
期刊：
AIDS (London, England)
影响因子：
--
作者：
Baxi SM;Greenblatt RM;Bacchetti P;Scherzer R;Minkoff H;Huang Y;Anastos K;Cohen M;Gange SJ;Young M;Shlipak MG;Gandhi M
通讯作者：
Gandhi M
Snagger：一个用户友好的程序，用于合并用于TAGSNP选择的其他信息。
影响因子：
3
作者：
Edlund, Christopher K.;Lee, Won H.;Li, Dalin;Van Den Berg, David J.;Conti, David V.
通讯作者：
Conti, David V.
DOI：
10.1097/qai.0b013e31819c3376
发表时间：
2009-04-15
期刊：
Journal of acquired immune deficiency syndromes (1999)
影响因子：
--
作者：
Gandhi M;Benet LZ;Bacchetti P;Kalinowski A;Anastos K;Wolfe AR;Young M;Cohen M;Minkoff H;Gange SJ;Greenblatt RM;Women's Interagency HIV Study
通讯作者：
Women's Interagency HIV Study
影响因子：
5.4
作者：
Barkan, SE;Melnick, SL;Feldman, J
通讯作者：
Feldman, J
DOI：
10.1086/597125
发表时间：
2009-03-15
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Haas DW;Gebretsadik T;Mayo G;Menon UN;Acosta EP;Shintani A;Floyd M;Stein CM;Wilkinson GR
通讯作者：
Wilkinson GR