Exploring Overlaps Between the Genomic and Environmental Determinants of LVH and Stroke: A Multicenter Study in West Africa.
Exploring Overlaps Between the Genomic and Environmental Determinants of LVH and Stroke: A Multicenter Study in West Africa.
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DOI：
10.1016/j.gheart.2017.01.001
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发表时间：
2017-06
期刊：
影响因子：
3.7
通讯作者：
SIREN Team as part of H3Africa Consortium
中科院分区：
文献类型：
--
作者：
Adeoye AM;Ovbiagele B;Kolo P;Appiah L;Aje A;Adebayo O;Sarfo F;Akinyemi J;Adekunle G;Agyekum F;Shidali V;Ogah O;Lackland D;Gebregziabher M;Arnett D;Tiwari HK;Akinyemi R;Olagoke OO;Oguntade AS;Olunuga T;Uwanruochi K;Jenkins C;Adadey P;Iheonye H;Owolabi L;Obiako R;Akinjopo S;Armstrong K;Akpalu A;Fakunle A;Saulson R;Aridegbe M;Olowoyo P;Osaigbovo G;Akpalu J;Fawale B;Adebayo P;Arulogun O;Ibinaiye P;Agunloye A;Ishaq N;Wahab K;Akpa O;Adeleye O;Bock-Oruma A;Ogbole G;Melikam S;Yaria J;Ogunjimi L;Salaam A;Sunmonu T;Makanjuola A;Farombi T;Laryea R;Uvere E;Kehinde S;Chukwuonye I;Azuh P;Komolafe M;Akintunde A;Obiabo O;Areo O;Kehinde I;Amusa AG;Owolabi M;SIREN Team as part of H3Africa Consortium
左心室肥厚 (LVH) 是否由与中风相似的基因组和环境危险因素决定，或者仅仅是中风的中间标志，目前尚不清楚。我们提出了一项研究计划和初步结果，以探索参与中风调查研究和教育网络 (SIREN) 研究的非洲人中 LVH 和中风的基因组和环境决定因素的重叠。 SIREN 是一项跨国、多中心研究，涉及急性中风患者以及从加纳和尼日利亚 9 个地点招募的年龄、种族和性别匹配的对照组。正在使用标准技术收集和比较中风和 LVH 的基因组和环境危险因素以及其他相关表型。这项初步分析仅包括 725 名中风患者（平均年龄 59.1±13.2 岁；54.3% 为男性）。 55% 的中风受试者患有 LVH，其中女性比例更高（51.6% vs 48.4%，p<0.001）。患有 LVH 的患者年龄较小（57.9±12.8 vs 60.6±13.4；p=0.006），平均收缩压和舒张压较高（167.1/99.5 mmHg vs 151.7/90.6 mmHg，p <0.001）。在 LVH 受试者中，就诊时血压 (BP) 不受控制很常见（76.2% vs 57.7%；p <0.001）。 LVH 的显着独立预测因素是年龄、< 45 岁（AOR = 1.91，95% CI：1.14 至 3.19）、女性（AOR = 2.01；95% CI：1.44 至 2.81）和舒张压 > 90mmHg（AOR = 2.10；95% CI：1.39 至3.19，p <0.001）。中风患者中 LVH 的患病率很高，尤其是年轻患者，这表明 LVH 存在遗传因素。高血压是中风和 LVH 的主要可改变危险因素。预计 SIREN 项目将阐明非洲人左心室肥厚和中风之间的多基因重叠（如果存在），从而确定 LVH 作为假定的中间心血管表型和治疗目标的作用，为降低非洲血统人群中风风险的干预措施提供信息。
Whether left ventricular hypertrophy (LVH) is determined by similar genomic and environmental risk factors with stroke, or is simply an intermediate stroke marker, is unknown. We present a research plan and preliminary findings to explore the overlap in the genomic and environmental determinants of LVH and stroke among Africans participating in the Stroke Investigative Research and Education Network (SIREN) study. SIREN is a transnational, multi-centre study involving acute stroke patients and age, ethnicity and sex-matched controls recruited from 9 sites in Ghana and Nigeria. Genomic and environmental risk factors and other relevant phenotypes for stroke and LVH are being collected and compared using standard techniques. This preliminary analysis included only 725 stroke patients (mean age 59.1±13.2 years; 54.3% males). Fifty- five percent of the stroke subjects had LVH with greater proportion among women (51.6% vs 48.4%, p<0.001). Those with LVH were younger (57.9±12.8 vs 60.6±13.4; p=0.006) and had higher mean systolic and diastolic BP (167.1/99.5 mmHg vs 151.7/90.6 mmHg, p <0.001). Uncontrolled blood pressure (BP) at presentation was prevalent in subjects with LVH (76.2% vs 57.7%; p <0.001). Significant independent predictors of LVH were age, < 45 years (AOR =1.91, 95% CI: 1.14 to 3.19), female gender (AOR = 2.01; 95% CI:1.44 to 2.81), and diastolic BP > 90mmHg (AOR = 2.10; 95% CI:1.39 to 3.19, p <0.001). The prevalence of LVH was high among stroke patients especially the younger ones suggesting a genetic component to LVH. Hypertension was a major modifiable risk factor for stroke as well as LVH. It is envisaged that the SIREN project will elucidate polygenic overlap (if present) between left ventricular hypertrophy and stroke among Africans, thereby defining the role of LVH as a putative intermediate cardiovascular phenotype and therapeutic target to inform interventions to reduce stroke risk in populations of African ancestry.
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影响因子：
3.7
作者：
Cole JW;Stine OC;Liu X;Pratap A;Cheng Y;Tallon LJ;Sadzewicz LK;Dueker N;Wozniak MA;Stern BJ;Meschia JF;Mitchell BD;Kittner SJ;O'Connell JR
通讯作者：
O'Connell JR
影响因子：
4.1
作者：
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通讯作者：
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影响因子：
8.3
作者：
DESIMONE, G;DEVEREUX, RB;LARAGH, JH
通讯作者：
LARAGH, JH
影响因子：
8.3
作者：
Drazner, MH;Dries, DL;Victor, RG
通讯作者：
Victor, RG
DOI：
10.1016/s0735-1097(02)03006-1
发表时间：
2003-03-19
影响因子：
24
作者：
East, MA;Jollis, JG;Peterson, ED
通讯作者：
Peterson, ED