Warfarin with fluoroquinolones, sulfonamides, or azole antifungals: interactions and the risk of hospitalization for gastrointestinal bleeding.
Warfarin with fluoroquinolones, sulfonamides, or azole antifungals: interactions and the risk of hospitalization for gastrointestinal bleeding.
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DOI：
10.1038/clpt.2008.150
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发表时间：
2008-11
影响因子：
6.7
通讯作者：
中科院分区：
文献类型：
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作者：
确定华法林和口服抗感染药物之间潜在的药代动力学相互作用是否会增加华法林使用者因胃肠道出血住院的风险。我们对美国医疗补助数据进行了巢式病例对照和病例交叉研究。使用Logistic回归来确定胃肠道出血与先前使用环丙沙星、左氧氟沙星、加替沙星、复方新诺明或氟康唑之间的关系，所有与未接触以及头孢氨苄与华法林之间的关系，头孢氨苄预计不会与华法林相互作用。所有检测的抗感染药物与未暴露者相比均表现出较高的优势比（OR）。以头孢氨苄作为参考类，复方新诺明（前6-10天OR:1.68 [95% CI: 1.21-2.33]）和氟康唑（前11-15天OR:2.09 [95% CI: 1.34-3.26]）的OR显著升高。接受过抗感染药物的华法林使用者出现胃肠道出血的风险显著增加。然而，只有复方新诺明和氟康唑与华法林有明显的药物-药物相互作用。
To determine whether a potential pharmacokinetic interaction between warfarin and orally administered anti-infectives increases the risk of hospitalization for gastrointestinal (GI) bleeding in warfarin users. We conducted a nested case-control and case-crossover study in US Medicaid data. Logistic regression was used to determine the association between GI bleeding and prior use of ciprofloxacin, levofloxacin, gatifloxacin, cotrimoxazole, or fluconazole, all versus no exposure and versus cephalexin, which would not be expected to interact with warfarin. All anti-infectives examined exhibited an elevated odds ratio (OR) vs. no exposure. Using cephalexin as the reference category, ORs for cotrimoxazole (OR:1.68 [95% CI:1.21–2.33] in the prior 6–10 days) and fluconazole (OR:2.09 [95% CI:1.34–3.26] in the prior 11–15 days) were significantly elevated. Warfarin users who had received an anti-infective agent showed a substantially increased risk of GI bleeding. Nonetheless, a drug-drug interaction with warfarin was evident only for cotrimoxazole and fluconazole.
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影响因子：
4.8
作者：
Gage, BF;Yan, Y;Radford, MJ
通讯作者：
Radford, MJ
影响因子：
4.1
作者：
McCall, KL;Scott, JC;Anderson, HG
通讯作者：
Anderson, HG
影响因子：
11.5
作者：
BRECKENRIDGE, AM
通讯作者：
BRECKENRIDGE, AM
影响因子：
6.7
作者：
Hamberg, A-K;Dahl, M-L;Jonsson, E. N.
通讯作者：
Jonsson, E. N.
DOI：
10.1016/s0002-8223(95)00158-1
发表时间：
1995-05-01
影响因子：
--
作者：
HARRIS, JE
通讯作者：
HARRIS, JE