Distinct intrinsic membrane properties determine differential information processing between main and accessory olfactory bulb mitral cells
Distinct intrinsic membrane properties determine differential information processing between main and accessory olfactory bulb mitral cells
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不同的内在膜特性决定了主嗅球二尖瓣细胞和副嗅球二尖瓣细胞之间的差异信息处理
DOI：
10.1016/j.neuroscience.2011.05.039
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发表时间：
2011
期刊：
影响因子：
3.3
通讯作者：
Stephan Wagner
中科院分区：
文献类型：
--
作者：
S. Zibman;Guy Shpak;Stephan Wagner
大多数哺乳动物依靠化学信息素（例如信息素）来调节它们的社交互动。最近的研究发现，化学信息素至少被两个不同的化学感觉系统感知：主嗅觉系统和辅助嗅觉系统，它们具有许多分子、细胞和解剖学特征。然而，这些系统之间的分工仍然不明确。之前我们认为这两种嗅觉系统处理感官信息的方式不同。在这项研究中，我们发现主嗅球和副嗅球的二尖瓣细胞（两个系统的第一个脑站）表现出明显不同的被动和主动内在特性，从而允许不同类型的信息处理。此外，我们发现副嗅球二尖瓣细胞分为三个具有不同放电特性的神经元亚群。这些神经元亚群可以整合到模拟神经元网络中，该网络忽略偶发刺激，同时放大对持久信号的反应。
Most mammals rely on semiochemicals, such as pheromones, to mediate their social interactions. Recent studies found that semiochemicals are perceived by at least two distinct chemosensory systems: the main and accessory olfactory systems, which share many molecular, cellular, and anatomical features. Nevertheless, the division of labor between these systems remained unclear. Previously we suggested that the two olfactory systems differ in the way they process sensory information. In this study we found that mitral cells of the main and accessory olfactory bulbs, the first brain stations of both systems, display markedly different passive and active intrinsic properties which permit distinct types of information processing. Moreover, we found that accessory olfactory bulb mitral cells are divided into three neuronal sub-populations with distinct firing properties. These neuronal sub-populations can be integrated in a simulated neuronal network that neglects episodic stimuli while amplifying reaction to long-lasting signals.
影响因子：
3.5
作者：
Restrepo, D;Arellano, J;Lin, WH
通讯作者：
Lin, WH