Pathogenicity and virulence of Marburg virus.

Pathogenicity and virulence of Marburg virus.
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DOI:
10.1080/21505594.2022.2054760
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发表时间:
2022-12
期刊:
影响因子:
5.2
通讯作者:
Hassan MM
Hassan MM
中科院分区:
生物学2区
文献类型:
--
作者:
Abir MH;Rahman T;Das A;Etu SN;Nafiz IH;Rakib A;Mitra S;Emran TB;Dhama K;Islam A;Siyadatpanah A;Mahmud S;Kim B;Hassan MM

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自1967年以来,马尔堡病毒(MARV)一直是一个主要问题,1998年和2004年发生了两次重大疫情。MARV感染会导致严重的出血热,引起器官功能障碍和死亡。在洞穴和矿井中接触果蝠以及人与人之间的传播是扩大非洲国家MARV疫情的主要因素。高达90%的病死率要求广泛研究与MARV感染相关的MARV疾病(MVD)。由于MARV的大规模爆发是罕见的,临床研究往往不足以提供确定MARV疾病治疗所需的大量数据。因此,一个全面的审查可能有助于尽量减少与未来的医学研究和改善MVD的临床管理的限制。在这篇综述中,我们试图分析和合并有关MARV疾病流行、病理生理学和管理方法的重要信息,以更好地了解这种致命病毒和相关感染。
Marburg virus (MARV) has been a major concern since 1967, with two major outbreaks occurring in 1998 and 2004. Infection from MARV results in severe hemorrhagic fever, causing organ dysfunction and death. Exposure to fruit bats in caves and mines, and human-to-human transmission had major roles in the amplification of MARV outbreaks in African countries. The high fatality rate of up to 90% demands the broad study of MARV diseases (MVD) that correspond with MARV infection. Since large outbreaks are rare for MARV, clinical investigations are often inadequate for providing the substantial data necessary to determine the treatment of MARV disease. Therefore, an overall review may contribute to minimizing the limitations associated with future medical research and improve the clinical management of MVD. In this review, we sought to analyze and amalgamate significant information regarding MARV disease epidemics, pathophysiology, and management approaches to provide a better understanding of this deadly virus and the associated infection.
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