The ocular hypotensive effect of saffron extract in primary open angle glaucoma: a pilot study.
The ocular hypotensive effect of saffron extract in primary open angle glaucoma: a pilot study.
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DOI：
10.1186/1472-6882-14-399
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发表时间：
2014-10-15
影响因子：
--
通讯作者：
Saadat S
中科院分区：
文献类型：
--
作者：
Jabbarpoor Bonyadi MH;Yazdani S;Saadat S
青光眼的进行性和发病率的不断增加使其治疗成为研究的重要目标。氧化损伤在青光眼发病机制中的作用使得抗氧化剂如甘草提取物成为潜在临床应用的有吸引力的靶点。在此，我们评估了水溶性甘草提取物对原发性开角型青光眼（POAG）患者眼内压（IOP）的影响。本前瞻性、比较性、随机干预性初步研究入组了34例接受噻吗洛尔和多佐胺滴眼液治疗的临床稳定POAG患者的34只眼。合格的受试者随机接受30 mg/天的龙蒿水提取物口服（17例受试者，17只眼）或安慰剂（17例受试者，17只眼），持续1个月，作为噻吗洛尔和多佐胺的辅助治疗。治疗后，两个研究组进入一个月的洗脱期。主要的结局指标是治疗期间和洗脱期后的IOP。平均基线IOP分别为12.9 ± 3.7 mmHg和14.0 ± 2.5 mmHg（p = 0.31）。治疗3周后，与对照组的13.5 ± 2.3 mmHg相比，Cortron组的IOP显著降低至10.9 ± 3.3 mmHg（p = 0.013）。在四周时，Calcifron组的IOP仍然显著较低（10.6 ± 3.0 vs 13.8 ± 2.2 mmHg，p = 0.001）。在洗脱期结束时，Calcifron组的IOP为12.9 ± 3.0 mmHg，对照组为14.2 ± 2.0 mmHg（p = 0.175）。在研究期间和洗脱期，没有患者发生副作用。口服甘草酸水提取物似乎对原发性开角型青光眼有眼扩张作用。这种效果在治疗三周后变得明显。本研究在国际临床试验注册平台（ICTRP）注册为IRCT 201201278832 N1。
The progressive nature of glaucoma and its growing incidence make its therapy an important target for research. The role of oxidative damage in the pathogenesis of glaucoma makes antioxidants such as saffron extract an attractive target for potential clinical use. Herein, we evaluate the effect of aqueous saffron extract on intraocular pressure (IOP) in eyes with primary open-angle glaucoma (POAG). Thirty-four eyes of 34 clinically stable POAG patients receiving treatment with timolol and dorzolamide eye drops were enrolled in this prospective, comparative, randomized interventional pilot study. Eligible subjects were randomized to receive 30 mg/day aqueous saffron extract orally (17 subjects, 17 eyes) or placebo (17 subjects, 17 eyes) for one month as an adjunct to timolol and dorzolamide. Following treatment, both study groups entered a one-month wash-out period. The main outcome measure was IOP during treatment and after the wash-out period. Mean baseline IOP was 12.9 ± 3.7 versus 14.0 ± 2.5 mmHg in the saffron and control groups, respectively (p = 0.31). After three weeks of treatment, IOP was significantly decreased to 10.9 ± 3.3 mmHg in the saffron group as compared to 13.5 ± 2.3 mmHg in the control group (p = 0.013). At four weeks, IOP was still significantly lower in the saffron group (10.6 ± 3.0 versus 13.8 ± 2.2 mmHg, p = 0.001). At the end of the wash-out period, IOP was 12.9 ± 3.0 in the saffron group versus 14.2 ± 2.0 mmHg in the control group (p = 0.175). None of the patients experienced side effects during the study and wash-out period. Oral aqueous saffron extract seems to exert an ocular hypotensive effect in primary open-angle glaucoma. This effect became evident after three weeks of therapy. The current study was registered at the International Clinical Trials Registry Platform (ICTRP) as IRCT201201278832N1.
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影响因子：
4.4
作者：
He, Yuan;Leung, Kar Wah;Ge, Jian
通讯作者：
Ge, Jian
影响因子：
--
作者：
Kassoff, A;Kassoff, J;Chew, EY
通讯作者：
Chew, EY
影响因子：
4.4
作者：
Maccarone, Rita;Di Marco, Stefano;Bisti, Silvia
通讯作者：
Bisti, Silvia
影响因子：
--
作者：
Akhondzadeh, Shahin;Fallah-Pour, Hasan;Khalighi-Cigaroudi, Farahnaz
通讯作者：
Khalighi-Cigaroudi, Farahnaz
影响因子：
7.2
作者：
Assimopoulou, AN;Sinakos, Z;Papageorgiou, VP
通讯作者：
Papageorgiou, VP