Prevention of Cervical Cancer in Sub-Saharan Africa: The Advantages and Challenges of HPV Vaccination.
Prevention of Cervical Cancer in Sub-Saharan Africa: The Advantages and Challenges of HPV Vaccination.
复制标题
DOI：
10.3390/vaccines6030061
复制
发表时间：
2018-09-08
期刊：
影响因子：
7.8
通讯作者：
Richmond R
中科院分区：
文献类型：
--
作者：
Black E;Richmond R
宫颈癌是撒哈拉以南非洲（SSA）的一个重要公共卫生问题，它是妇女癌症的第二大原因，也是女性癌症死亡的主要原因。发病率和死亡率大大高于高收入国家的人口为基础的筛查计划，但在SSA实施筛查计划迄今已被证明是具有挑战性的，由于财政，后勤和社会文化因素。人乳头瘤病毒（HPV）疫苗接种是一种有效的宫颈癌一级预防方法，并提供了一个机会，以减少宫颈癌在SSA的负担。由于一些撒哈拉以南非洲国家现在有资格获得全球疫苗和免疫联盟（GAVI）对疫苗引进的支持，现在是时候考虑阻碍和促进撒哈拉以南非洲疫苗计划实施的因素了。本文介绍了撒哈拉以南非洲国家宫颈癌的流行病学特征和HPV疫苗在撒哈拉以南非洲国家的实施现状。卢旺达在其国家HPV免疫接种计划中实现高疫苗接种覆盖率的经验被用作案例研究，以探索在SSA设计和实施HPV疫苗接种计划的有效方法。卢旺达成功实施该方案的关键因素包括政府对该方案的所有权和支持、以学校为基础的实施、社会动员以及帮助失学女童的战略。这些发现可能适用于其他计划接种HPV疫苗的SSA国家。
Cervical cancer is a critical public health issue in sub-Saharan Africa (SSA), where it is the second leading cause of cancer among women and the leading cause of female cancer deaths. Incidence and mortality rates are substantially higher than in high-income countries with population-based screening programs, yet implementing screening programs in SSA has so far proven to be challenging due to financial, logistical, and sociocultural factors. Human Papillomavirus (HPV) vaccination is an effective approach for primary prevention of cervical cancer and presents an opportunity to reduce the burden from cervical cancer in SSA. With a number of SSA countries now eligible for Global Alliance for Vaccines and Immunization (GAVI) support for vaccine introduction, it is timely to consider the factors that impede and facilitate implementation of vaccine programs in SSA. This article describes epidemiological features of cervical cancer in SSA and the current status of HPV vaccine implementation in SSA countries. Rwanda’s experience of achieving high vaccination coverage in their national HPV immunization program is used as a case study to explore effective approaches to the design and implementation of HPV vaccination programs in SSA. Key factors in Rwanda’s successful implementation included government ownership and support for the program, school-based delivery, social mobilization, and strategies for reaching out-of-school girls. These findings might usefully be applied to other SSA countries planning for HPV vaccination.
登录
查看更多内容
DOI：
10.2471/blt.11.097253
发表时间：
2012-08-01
期刊：
Bulletin of the World Health Organization: International Journal of Public Health
影响因子：
--
作者：
Binagwaho, Agnes;Wagner, Claire M;Ngabo, Fidele
通讯作者：
Ngabo, Fidele
影响因子：
3.7
作者：
Campos NG;Sharma M;Clark A;Kim JJ;Resch SC
通讯作者：
Resch SC
影响因子：
3.7
作者：
Perlman S;Wamai RG;Bain PA;Welty T;Welty E;Ogembo JG
通讯作者：
Ogembo JG
影响因子：
56.3
作者：
Drolet, Melanie;Benard, Elodie;Brisson, Marc
通讯作者：
Brisson, Marc
影响因子：
3.4
作者：
Michelow, Pamela;Firnhaber, Cynthia
通讯作者：
Firnhaber, Cynthia