Knowledge and awareness of HPV vaccine and acceptability to vaccinate in sub-Saharan Africa: a systematic review.
Knowledge and awareness of HPV vaccine and acceptability to vaccinate in sub-Saharan Africa: a systematic review.
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DOI：
10.1371/journal.pone.0090912
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Ogembo JG
中科院分区：
文献类型：
--
作者：
Perlman S;Wamai RG;Bain PA;Welty T;Welty E;Ogembo JG
我们评估了撒哈拉以南非洲（SSA）国家对宫颈癌、HPV和HPV疫苗的知识和认识，以及接种疫苗的意愿和可接受性。我们进一步确定了符合两项GAVI联盟资格标准的国家，以支持全国HPV疫苗接种。我们对同行评议的研究进行了系统回顾，这些研究涉及宫颈癌、HPV和HPV疫苗的知识和意识，以及接种疫苗的意愿和可接受性。1990-2011年撒南非洲国家白喉-破伤风-百日咳（三联疫苗）疫苗覆盖率趋势摘自世界卫生组织数据库。审查显示，HPV疫苗的意愿和可接受性较高，但对宫颈癌、HPV或HPV疫苗的知识和认识水平较低。我们发现只有6个国家符合全球疫苗和免疫联盟支持引入HPV疫苗的两项要求：1）在平均规模的地区为不少于50%的目标疫苗接种队列提供多剂量疫苗的能力，以及2）在全国范围内实现超过70%的DTP 3疫苗覆盖率。从2008年到2011年，除毛里塔尼亚和尼日利亚外，所有撒哈拉以南非洲国家的三联疫苗接种率均达到或保持在70%或以上。迫切需要更多的教育来告知公众HPV，HPV疫苗和宫颈癌，特别是关键的人口统计数据（青少年，父母和医疗保健专业人员），以利用HPV疫苗的高水平意愿和可接受性来成功实施HPV疫苗接种计划。大多数撒哈拉以南非洲国家没有准备好根据全球疫苗和免疫联盟支持引进疫苗的资格标准推出国家HPV疫苗接种。在已经达到70% DTP 3覆盖率的国家，需要推出试点计划，以确定向青少年提供HPV疫苗的最佳做法和战略，并获得GAVI联盟的支持。
We assessed the knowledge and awareness of cervical cancer, HPV and HPV vaccine, and willingness and acceptability to vaccinate in sub-Saharan African (SSA) countries. We further identified countries that fulfill the two GAVI Alliance eligibility criteria to support nationwide HPV vaccination. We conducted a systematic review of peer-reviewed studies on the knowledge and awareness of cervical cancer, HPV and HPV vaccine, and willingness and acceptability to vaccinate. Trends in Diphtheria-tetanus-pertussis (DTP3) vaccine coverage in SSA countries from 1990–2011 were extracted from the World Health Organization database. The review revealed high levels of willingness and acceptability of HPV vaccine but low levels of knowledge and awareness of cervical cancer, HPV or HPV vaccine. We identified only six countries to have met the two GAVI Alliance requirements for supporting introduction of HPV vaccine: 1) the ability to deliver multi-dose vaccines for no less than 50% of the target vaccination cohort in an average size district, and 2) achieving over 70% coverage of DTP3 vaccine nationally. From 2008 through 2011 all SSA countries, with the exception of Mauritania and Nigeria, have reached or maintained DTP3 coverage at 70% or above. There is an urgent need for more education to inform the public about HPV, HPV vaccine, and cervical cancer, particularly to key demographics, (adolescents, parents and healthcare professionals), to leverage high levels of willingness and acceptability of HPV vaccine towards successful implementation of HPV vaccination programs. There is unpreparedness in most SSA countries to roll out national HPV vaccination as per the GAVI Alliance eligibility criteria for supporting introduction of the vaccine. In countries that have met 70% DTP3 coverage, pilot programs need to be rolled out to identify the best practice and strategies for delivering HPV vaccines to adolescents and also to qualify for GAVI Alliance support.
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DOI：
10.2471/blt.11.097253
发表时间：
2012-08-01
期刊：
Bulletin of the World Health Organization: International Journal of Public Health
影响因子：
--
作者：
Binagwaho, Agnes;Wagner, Claire M;Ngabo, Fidele
通讯作者：
Ngabo, Fidele
影响因子：
5.5
作者：
Bean, Sandra J.
通讯作者：
Bean, Sandra J.
影响因子：
3.7
作者：
DiAngi, Yumi Taylor;Panozzo, Catherine A.;Brewer, Noel T.
通讯作者：
Brewer, Noel T.
影响因子：
5.9
作者：
Ayissi, Claudine Akono;Wamai, Richard G.;Ogembo, Javier Gordon
通讯作者：
Ogembo, Javier Gordon
影响因子：
5.5
作者：
Becker-Dreps, Sylvia;Otieno, Walter Agingu;Smith, Jennifer S.
通讯作者：
Smith, Jennifer S.