Erythrocyte glutathione transferase: a non-antibody biomarker for systemic sclerosis, which correlates with severity and activity of the disease.
Erythrocyte glutathione transferase: a non-antibody biomarker for systemic sclerosis, which correlates with severity and activity of the disease.
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DOI：
10.1038/cddis.2013.255
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发表时间：
2013-07-25
影响因子：
9
通讯作者：
Ricci, G.
中科院分区：
文献类型：
--
作者：
Fabrini, R.;Rosato, E.;Gigante, A.;Bocedi, A.;Cianci, R.;Barbano, B.;Del Grosso, E.;Ricci, F.;Zingaretti, V.;Salsano, F.;Ricci, G.
红细胞谷胱甘肽转移酶（e-GST）是一种在肾病患者中高表达的解毒酶，最近被用作血液毒性的生物标志物。系统性硬化症（SSc）的特征在于皮肤和内脏的内皮功能障碍和纤维化。肾受累在SSc患者中是常见的。在此，我们发现e-GST在SSc患者（n=102）中高表达，并与Medsger DSS和DAI Valentini指数相关（R2=0.49，P<0.0001），该指数量化了该疾病的严重程度和活动性。有趣的是，e-GST与肾脏或其他特定器官的损伤无关。e-GST超表达似乎与一种因子的存在有关（即，毒素），触发自身免疫性疾病，而不是特定器官的损伤或氧化应激。e-GST可能被提议作为一种创新的非抗体生物标志物，用于检查这种疾病的进展和新的治疗策略的效率。
Erythrocyte glutathione transferase (e-GST) is a detoxifying enzyme hyper-expressed in nephropathic patients and used recently as a biomarker for blood toxicity. Systemic sclerosis (SSc) is characterized by endothelial dysfunction and fibrosis of the skin and internal organs. Renal involvement is frequent in SSc patients. Here we show that e-GST is hyper-expressed in SSc patients (n=102) and correlates (R2=0.49, P<0.0001) with the Medsger DSS and DAI Valentini indices that quantify the severity and activity of this disease. Interestingly, e-GST does not correlate with the impairment of kidney or other specific organs taken separately. e-GST hyper-expression seems to be linked to the presence of a factor (i.e., toxin) that triggers the autoimmune disease, and not to the damage of specific organs or to oxidative stress. e-GST may be proposed as an innovative non-antibody biomarker for SSc useful to check the progress of this disease and the efficiency of new therapeutic strategies.
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影响因子：
5.5
作者：
Gigante, Antonietta;Rosato, Edoardo;Salsano, Felice
通讯作者：
Salsano, Felice
影响因子：
27.4
作者：
Steen, Virginia D.;Medsger, Thomas A.
通讯作者：
Medsger, Thomas A.
影响因子：
2.3
作者：
Steen, VD
通讯作者：
Steen, VD
影响因子：
5
作者：
Broen, Jasper C. A.;Coenen, Marieke J. H.;Radstake, Timothy R. D. J.
通讯作者：
Radstake, Timothy R. D. J.
影响因子：
9
作者：
Noce, A.;Ferrannini, M.;Ricci, G.
通讯作者：
Ricci, G.