Effects of tumour acidification with glucose+MIBG on the spontaneous metastatic potential of two murine cell lines
Effects of tumour acidification with glucose+MIBG on the spontaneous metastatic potential of two murine cell lines
复制标题
葡萄糖 MIBG 肿瘤酸化对两种小鼠细胞系自发转移潜能的影响
作者：
Tuula M Kalliomäki;Tuula M Kalliomäki;R. Hill;R. Hill
除了缺氧，酸性细胞外pH(Phe)也被认为是实体肿瘤的微环境特征之一。一些研究已经研究了增加肿瘤酸度的方法，以提高某些药物的肿瘤特异性靶向性和热疗的有效性。然而，先前的数据表明，将小鼠肿瘤细胞暴露在培养的酸性条件下，当随后注射到小鼠体内时，可以增强它们的转移潜力，这引发了人们的担忧，即故意的肿瘤酸化可能会增加转移的可能性。在这项研究中，我们研究了体内肿瘤酸化和低氧对小鼠KHT-C纤维肉瘤和B16F1黑色素瘤细胞系自发转移潜能的影响。通过pH电极的测量，肿瘤特异性细胞外酸度的增加是通过每天在腹膜内注射间碘-苄基胍(MIBG)和/或葡萄糖来实现的。这种在肿瘤生长过程中酸化肿瘤的方法并没有显著增强这两种小鼠细胞系的自发转移潜能。
In addition to hypoxia, acidic extracellular pH (pHe) is recognised as one of the microenvironmental characteristics of solid tumours. A number of studies have examined ways to increase tumour acidity in order to improve tumour-specific targeting of certain drugs and the effectiveness of hyperthermia. However, previous data have shown that exposure of murine tumour cells to acid conditions in culture can enhance their metastatic potential when injected subsequently into mice, raising the concern that deliberate tumour acidification might increase the probability of metastasis. In this study, we examined the effects of in vivo tumour acidification and hypoxia on the spontaneous metastatic potential of the murine KHT-C fibrosarcoma and B16F1 melanoma cell lines. A tumour-specific increase in extracellular acidity, demonstrated by measurements with pH electrodes, was achieved by daily intraperitoneal injections of meta-iodo-benzylguanidine (MIBG) and/or glucose. This method of tumour acidification during tumour growth did not significantly enhance the spontaneous metastatic potential of the two murine cell lines.
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影响因子：
11.2
作者：
R. Zhou;N. Bansal;D. Leeper;J. Glickson
通讯作者：
R. Zhou;N. Bansal;D. Leeper;J. Glickson
影响因子：
50.3
作者：
Blouw, B;Song, HQ;Bergers, G
通讯作者：
Bergers, G
适应低 pH 值生长的人类黑色素瘤细胞缺乏克拉布特里效应：呼吸抑制剂可逆转。
DOI：
--
发表时间：
2001
期刊：
Cancer research.
影响因子：
--
作者：
Burd,R;Wachsberger,PR;Biaglow,JE;Wahl,ML;Lee,I;Leeper,DB
通讯作者：
Leeper,DB
影响因子：
8.8
作者：
Siemann, D W;Lord, E M;Keng, P C;Wheeler, K T
通讯作者：
Wheeler, K T
DOI：
10.3109/02656739809018231
发表时间：
1998
期刊：
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
影响因子：
--
作者：
Leeper,DB;Engin,K;Wang,JH;Cater,JR;Li,DJ
通讯作者：
Li,DJ