Viral dosing of influenza A infection reveals involvement of RIPK3 and FADD, but not MLKL.
Viral dosing of influenza A infection reveals involvement of RIPK3 and FADD, but not MLKL.
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DOI：
10.1038/s41419-021-03746-0
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发表时间：
2021-05-11
影响因子：
9
通讯作者：
Vandenabeele P
中科院分区：
文献类型：
--
作者：
Oltean T;Van San E;Divert T;Vanden Berghe T;Saelens X;Maelfait J;Takahashi N;Vandenabeele P
据报道，RIPK3在体内对甲型流感病毒(IAV)具有重要的保护作用。在这里，我们表明，RIPK3对体内预防IAV感染的要求只有在IAV挑战的有限剂量范围内才明显。我们发现，这种保护结果独立于RIPK3激酶活性和MLKL。这表明保护需要的是RIPK3的平台功能，而不是它的激酶活性，这表明RIPK3的功能独立于坏死性下垂。根据这一发现，我们表明FADD依赖的细胞凋亡在预防IAV感染方面具有关键的额外作用。总之，我们表明RIPK3在一个狭窄的攻击剂量范围内通过一种独立于其激酶活性和诱导坏死性下垂的能力的机制对IAV起到保护作用。
RIPK3 was reported to play an important role in the protection against influenza A virus (IAV) in vivo. Here we show that the requirement of RIPK3 for protection against IAV infection in vivo is only apparent within a limited dose range of IAV challenge. We found that this protective outcome is independent from RIPK3 kinase activity and from MLKL. This shows that platform function of RIPK3 rather than its kinase activity is required for protection, suggesting that a RIPK3 function independent of necroptosis is implicated. In line with this finding, we show that FADD-dependent apoptosis has a crucial additional effect in protection against IAV infection. Altogether, we show that RIPK3 contributes to protection against IAV in a narrow challenge dose range by a mechanism that is independent of its kinase activity and its capacity to induce necroptosis.
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影响因子：
16
作者：
Mandal P;Berger SB;Pillay S;Moriwaki K;Huang C;Guo H;Lich JD;Finger J;Kasparcova V;Votta B;Ouellette M;King BW;Wisnoski D;Lakdawala AS;DeMartino MP;Casillas LN;Haile PA;Sehon CA;Marquis RW;Upton J;Daley-Bauer LP;Roback L;Ramia N;Dovey CM;Carette JE;Chan FK;Bertin J;Gough PJ;Mocarski ES;Kaiser WJ
通讯作者：
Kaiser WJ
caspase-8脚手架函数和MLKL调节TLR3下游的NLRP3炎性体激活。
影响因子：
16.6
作者：
Kang, Seokwon;Fernandes-Alnemri, Teresa;Rogers, Corey;Mayes, Lindsey;Wang, Ying;Dillon, Christopher;Roback, Linda;Kaiser, William;Oberst, Andrew;Sagara, Junji;Fitzgerald, Katherine A.;Green, Douglas R.;Zhang, Jianke;Mocarski, Edward S.;Alnemri, Emad S.
通讯作者：
Alnemri, Emad S.
影响因子：
30.3
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Balachandran S
影响因子：
30.3
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Thapa RJ;Ingram JP;Ragan KB;Nogusa S;Boyd DF;Benitez AA;Sridharan H;Kosoff R;Shubina M;Landsteiner VJ;Andrake M;Vogel P;Sigal LJ;tenOever BR;Thomas PG;Upton JW;Balachandran S
通讯作者：
Balachandran S
影响因子：
82.9
作者：
Neirynck, S;Deroo, T;Fiers, W
通讯作者：
Fiers, W