circVAMP3 Drives CAPRIN1 Phase Separation and Inhibits Hepatocellular Carcinoma by Suppressing c-Myc Translation.
circVAMP3 Drives CAPRIN1 Phase Separation and Inhibits Hepatocellular Carcinoma by Suppressing c-Myc Translation.
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circVAMP3 驱动 CAPRIN1 相分离并通过抑制 c–Myc 翻译抑制肝细胞癌
DOI：
10.1002/advs.202103817
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发表时间：
2022-03
期刊：
影响因子：
--
通讯作者：
Zhao F
中科院分区：
文献类型：
--
作者：
Chen S;Cao X;Zhang J;Wu W;Zhang B;Zhao F
先前的研究已经确定了环状RNA（circRNA）在人类癌症中的调节作用。然而，circRNA在肝细胞癌（HCC）中的分子机制仍不清楚。本研究筛选了HCC中circRNA的表达谱，并鉴定了circVAMP 3作为HCC组织中显著下调的circRNA。circVAMP 3低表达的HCC患者预后差。circVAMP 3通过驱动CAPRIN 1的相分离和促进细胞内应激颗粒的形成，在体外和体内负调控HCC细胞的增殖和转移，其可以通过抑制c-Myc翻译下调Myc原癌基因蛋白的蛋白水平。此外，circVAMP 3在许多人体组织中广泛表达，并在相关癌症中下调。因此，circVAMP 3是HCC的潜在预后指标，并可作为HCC治疗的治疗靶点。
Previous studies have identified the regulatory roles of circular RNAs (circRNAs) in human cancers. However, the molecular mechanisms of circRNAs in hepatocellular carcinoma (HCC) remain largely unknown. This study screens the expression profile of circRNAs in HCC and identifies circVAMP3 as a significantly downregulated circRNA in HCC tissues. HCC patients with low circVAMP3 expression present poor prognosis. circVAMP3 negatively regulates the proliferation and metastasis of HCC cells in vitro and in vivo by driving phase separation of CAPRIN1 and promoting stress granule formation in cells, which can downregulate the protein level of Myc proto‐oncogene protein by inhibiting c‐Myc translation. Furthermore, circVAMP3 is widely expressed in many human tissues and is downregulated in related cancers. Therefore, circVAMP3 is a potential prognostic indicator for HCC and may serve as a therapeutic target for HCC treatment.
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影响因子：
14.9
作者：
Kuleshov MV;Jones MR;Rouillard AD;Fernandez NF;Duan Q;Wang Z;Koplev S;Jenkins SL;Jagodnik KM;Lachmann A;McDermott MG;Monteiro CD;Gundersen GW;Ma'ayan A
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Ma'ayan A
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64.8
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Rosen, Michael K.
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13.5
作者：
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影响因子：
4.1
作者：
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通讯作者：
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影响因子：
11.2
作者：
Hsiao KY;Lin YC;Gupta SK;Chang N;Yen L;Sun HS;Tsai SJ
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