Palatal seam disintegration: to die or not to die? that is no longer the question.
Palatal seam disintegration: to die or not to die? that is no longer the question.
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DOI：
10.1002/dvdy.21599
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发表时间：
2008-10
影响因子：
2.5
通讯作者：
Nawshad, Ali
中科院分区：
文献类型：
--
作者：
Nawshad, Ali
腭架融合形成的内侧上皮缝（MES）是腭发育的关键步骤。MES的完全解体是腭部与周围间充质细胞融合的最后阶段。一般来说，腭缝崩解的机制并不十分复杂，但考虑到大量的相互作用成分;它们复杂的电路，包括前馈，反馈和串扰;以及相互作用的动力学问题，这个简单的机制可能很难解释。由于这种复杂性，看似简单但非常重要的问题仍然没有答案。其中一个问题涉及腭缝的命运。这些问题可以通过基础生物学研究（细胞、结构）和最新分子生物学决定因素（遗传/染色细胞谱系、基因活性、激酶/酶活性）的详细和广泛的定量实验以及动物模型（敲除、转基因）方法来回答。系统生物学和细胞动力学在细胞MES功能中起着至关重要的作用;遗漏这些关键因素可能导致对MES命运的不准确理解。关于腭缝崩解机制的研究取得了很大进展。目前对腭缝崩解的理解表明上皮-间充质转化和/或程序性细胞死亡是MES崩解的两种最常见机制。在这篇综述中，我将讨论这两种机制以及它们之间的差异。
Formation of the medial epithelial seam (MES) by palatal shelf fusion is a crucial step of palate development. Complete disintegration of the MES is the final essential phase of palatal confluency with surrounding mesenchymal cells. In general, the mechanisms of palatal seam disintegration are not overwhelmingly complex, but given the large number of interacting constituents; their complicated circuitry involving feedforward, feedback, and crosstalk; and the fact that the kinetics of interaction matter, this otherwise simple mechanism can be quite difficult to interpret. As a result of this complexity, apparently simple but highly important questions remain unanswered. One such question pertains to the fate of the palatal seam. Such questions may be answered by detailed and extensive quantitative experimentation of basic biological studies (cellular, structural) and the newest molecular biological determinants (genetic/dye cell lineage, gene activity, kinase/enzyme activity), as well as animal model (knockouts, transgenic) approaches. System biology and cellular kinetics play a crucial role in cellular MES function; omissions of such critical contributors may lead to inaccurate understanding of the fate of MES. Excellent progress has been made relevant to elucidation of the mechanism(s) of palatal seam disintegration. Current understanding of palatal seam disintegration suggests epithelial–mesenchymal transition and/or programmed cell death as two most common mechanisms of MES disintegration. In this review, I discuss those two mechanisms and the differences between them.
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