Inflammation and bone mineral density: A Mendelian randomization study.
Inflammation and bone mineral density: A Mendelian randomization study.
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DOI：
10.1038/s41598-017-09080-w
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发表时间：
2017-08-17
影响因子：
4.6
通讯作者：
Schooling CM
中科院分区：
文献类型：
--
作者：
Huang JV;Schooling CM
骨质疏松症是一种常见的与年龄有关的疾病，导致骨质疏松性骨折的增加，并导致严重的痛苦和残疾。炎症可能会导致骨质疏松症，就像它对许多其他慢性疾病一样。我们研究了炎症是否与骨质疏松症的病因学相关，从骨矿物质密度（BMD）评估，作为一个新的潜在的干预目标，或者它是否是骨质疏松症的症状/生物标志物。我们从全基因组关联研究中获得了炎症标志物的遗传预测因子，并将其应用于BMD的大型全基因组关联研究。采用双样本孟德尔随机化方法，我们获得了高敏C反应蛋白（hsCRP）对前臂、股骨颈和腰椎BMD影响的无混杂估计值。在去除可能通过肥胖相关性状起作用的潜在多效性单核苷酸多态性（SNPs）后，基于来自包括CRP在内的基因的16个SNPs的hsCRP与BMD无关。在这项研究中，hsCRP与低BMD的因果关系不明显。
Osteoporosis is a common age-related disorder leading to an increase in osteoporotic fractures and resulting in significant suffering and disability. Inflammation may contribute to osteoporosis, as it does to many other chronic diseases. We examined whether inflammation is etiologically relevant to osteoporosis, assessed from bone mineral density (BMD), as a new potential target of intervention, or whether it is a symptom/biomarker of osteoporosis. We obtained genetic predictors of inflammatory markers from genome-wide association studies and applied them to a large genome wide association study of BMD. Using two-sample Mendelian randomization, we obtained unconfounded estimates of the effect of high-sensitivity C-reactive protein (hsCRP) on BMD at the forearm, femoral neck, and lumbar spine. After removing potentially pleiotropic single nucleotide polymorphisms (SNPs) possibly acting via obesity-related traits, hsCRP, based on 16 SNPs from genes including CRP, was not associated with BMD. A causal relation of hsCRP with lower BMD was not evident in this study.
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影响因子：
37.8
作者：
Dehghan A;Dupuis J;Barbalic M;Bis JC;Eiriksdottir G;Lu C;Pellikka N;Wallaschofski H;Kettunen J;Henneman P;Baumert J;Strachan DP;Fuchsberger C;Vitart V;Wilson JF;Paré G;Naitza S;Rudock ME;Surakka I;de Geus EJ;Alizadeh BZ;Guralnik J;Shuldiner A;Tanaka T;Zee RY;Schnabel RB;Nambi V;Kavousi M;Ripatti S;Nauck M;Smith NL;Smith AV;Sundvall J;Scheet P;Liu Y;Ruokonen A;Rose LM;Larson MG;Hoogeveen RC;Freimer NB;Teumer A;Tracy RP;Launer LJ;Buring JE;Yamamoto JF;Folsom AR;Sijbrands EJ;Pankow J;Elliott P;Keaney JF;Sun W;Sarin AP;Fontes JD;Badola S;Astor BC;Hofman A;Pouta A;Werdan K;Greiser KH;Kuss O;Meyer zu Schwabedissen HE;Thiery J;Jamshidi Y;Nolte IM;Soranzo N;Spector TD;Völzke H;Parker AN;Aspelund T;Bates D;Young L;Tsui K;Siscovick DS;Guo X;Rotter JI;Uda M;Schlessinger D;Rudan I;Hicks AA;Penninx BW;Thorand B;Gieger C;Coresh J;Willemsen G;Harris TB;Uitterlinden AG;Järvelin MR;Rice K;Radke D;Salomaa V;Willems van Dijk K;Boerwinkle E;Vasan RS;Ferrucci L;Gibson QD;Bandinelli S;Snieder H;Boomsma DI;Xiao X;Campbell H;Hayward C;Pramstaller PP;van Duijn CM;Peltonen L;Psaty BM;Gudnason V;Ridker PM;Homuth G;Koenig W;Ballantyne CM;Witteman JC;Benjamin EJ;Perola M;Chasman DI
通讯作者：
Chasman DI
影响因子：
2.1
作者：
Bowden J;Davey Smith G;Haycock PC;Burgess S
通讯作者：
Burgess S
影响因子：
--
作者：
Lim HS;Park YH;Kim SK
通讯作者：
Kim SK
影响因子：
3.4
作者：
Cantatore, FP;Corrado, A;Melillo, N
通讯作者：
Melillo, N
影响因子：
6.2
作者：
Burge, Russel;Dawson-Hughes, Bess;Tosteson, Anna
通讯作者：
Tosteson, Anna