Passaged goat costal chondrocytes provide a feasible cell source for temporomandibular joint tissue engineering.
Passaged goat costal chondrocytes provide a feasible cell source for temporomandibular joint tissue engineering.
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DOI：
10.1007/s10439-008-9572-2
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发表时间：
2008-12
影响因子：
3.8
通讯作者：
Athanasiou, Kyriacos A.
中科院分区：
文献类型：
--
作者：
Anderson, Deirdre E. J.;Athanasiou, Kyriacos A.
Costal cartilage is commonly harvested for various types of facial reconstructive surgery. The ability of costal chondrocytes (CCs) to produce relevant extracellular matrix, including glycosaminoglycans (GAGs), collagen type I, and collagen type II, makes them an appealing cell source for fibrocartilage tissue engineering. In order to obtain enough cells for tissue engineering, however, cell expansion will likely be necessary. This study examined CCs at passages 0, 1, 3, and 5, as well as temporomandibular (TMJ) disc cells, in a scaffoldless tissue engineering approach. TMJ disc constructs had over twice the collagen content of any other group, as well as the largest tensile properties; however, the substantial contraction of the constructs and limited cell numbers make it a non-feasible cell source for tissue engineering. In general, statistical differences in mechanical properties or total collagen content of the various CC groups were not observed; however, significantly more GAG was produced in the passaged CCs than the primary CCs. More collagen type II was also observed in some of the passaged cell groups than in passage 0. These results suggest not only feasibility but potential superiority of passaged CCs over primary CCs, which may lead to a functional engineered fibrocartilage tissue.
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影响因子：
6.9
作者：
Detamore, MS;Orfanos, JG;Athanasiou, KA
通讯作者：
Athanasiou, KA
DOI：
10.1016/j.cxom.2005.05.004
发表时间：
2005-09-01
影响因子：
--
作者：
Caccamese, John F Jr;Ruiz, Ramon L;Costello, Bernard J
通讯作者：
Costello, Bernard J
影响因子：
4.6
作者：
GAGE, JP;SHAW, RM;MOLONEY, FB
通讯作者：
MOLONEY, FB
影响因子：
--
作者：
Johnson, TS;Xu, JW;Yaremchuk, MJ
通讯作者：
Yaremchuk, MJ
影响因子：
15.9
作者：
GOLDRING, MB;BIRKHEAD, J;KRANE, SM
通讯作者：
KRANE, SM