Getting to the heart of myocardial stem cells and cell therapy.
Getting to the heart of myocardial stem cells and cell therapy.
复制标题
深入了解心肌干细胞和细胞治疗的核心。
DOI：
10.1161/circulationaha.109.858019
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发表时间：
2011
期刊：
影响因子：
37.8
通讯作者：
Garry,DanielJ
中科院分区：
文献类型：
--
作者：
Rasmussen,TaraL;Raveendran,Ganesh;Zhang,Jianyi;Garry,DanielJ
Heart disease is both common and deadly. Cardiovascular disease is a global epidemic, because it is the number 1 cause of death worldwide, and it is estimated that 1 in 3 adults in the United States have cardiovascular disease. 1 Although a number of pioneering initiatives have transformed our treatment of cardiovascular disease, new therapies are required to further address the growing incidence of this deadly disease. Intense interest has focused on regenerative medicine as an emerging strategy for chronic diseases such as cardiovascular disease.A number of human tissues, including skin, 2 gut, liver, 3–6 and skeletal muscle3, 7 have a tremendous regenerative capacity. For example, skeletal muscle is able to completely restore its cellular architecture and function after an injury that destroys 80% of the muscle. 7, 8 This regenerative response lacks a fibroproliferative response (ie, formation of scar) and is associated with restoration of the vasculature, myofibers, and extracellular matrix. Compared with skeletal muscle, the regenerative capacity of the adult heart is more limited. Recent studies suggest that the adult heart is capable of cellular turnover and limited regeneration after injury, although the networks that govern this process are ill defined. The use of genetic mouse models and molecular biological techniques is unveiling cell populations, pathways, and extracellular cues that may direct cardiac regeneration and provide a platform for further investigation. The goal of the present review is to examine the endogenous regenerative capacity of the adult heart and highlight new experimental regenerative therapies aimed at restoring myocardial architecture and function.
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影响因子：
2.7
作者：
Olguin, HC;Olwin, BB
通讯作者：
Olwin, BB
节段三体小鼠模型中 Igf2r 印记基因的表达和甲基化定量。
影响因子：
4.4
作者：
T. Vacík;J. Forejt
通讯作者：
J. Forejt
影响因子：
37.8
作者：
Perin, EC;Dohmann, HFR;Willerson, JT
通讯作者：
Willerson, JT
DOI：
10.1152/ajpheart.1996.271.5.h2183
发表时间：
1996-11
期刊：
The American journal of physiology
影响因子：
--
作者：
M. Soonpaa;KYUNG KEUN Kim;L. Pajak;M. Franklin;L. Field
通讯作者：
M. Soonpaa;KYUNG KEUN Kim;L. Pajak;M. Franklin;L. Field
影响因子：
64.8
作者：
通讯作者：
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