Types of taste circuits synaptically linked to a few geniculate ganglion neurons.
Types of taste circuits synaptically linked to a few geniculate ganglion neurons.
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DOI：
10.1002/cne.21869
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发表时间：
2008-12-20
影响因子：
2.5
通讯作者：
Whitehead, Mark C.
中科院分区：
文献类型：
--
作者：
Zaidi, Faisal N.;Todd, Krista;Enquist, Lynn;Whitehead, Mark C.
关键词：
本研究评估的中央电路，由非常小的子集的总人口的膝状体神经节细胞的突触参与测试的假设，味觉神经节细胞是异质性的，在他们的中央连接。我们使用跨突触顺行性伪狂犬病病毒标记的菌状味觉乳头感染单个或少量的膝状神经节细胞，连同与它们连接的中枢神经元，以定义味觉通路中突触连接神经元的差异模式。标记的脑细胞位于已知的味觉区域内，包括孤束核（NST）的吻侧中央分部（RC），膝状体轴突突触的主要部位，以及包含大多数投射到脑桥旁核（PBN）的细胞的部位。细胞还位于头侧外侧NST亚区（RL），三叉神经和稀疏膝状体输入的部位，以及腹侧NST（V）和延髓网状结构（RF），尾侧脑干通路导致反射性orthodontic功能。病例之间的比较，每一个随机的，非常小的标记膝状体神经元的子集，揭示了“类型”的中央神经回路一致的差异参与的上升或本地，髓内通路由不同类别的神经节细胞。我们的结论是，味觉神经节细胞是异质性的，在其中央连接，一些从事，主要是，上升的“丘系”，味觉通路，电路与高阶的歧视和稳态功能，其他从事的“本地”，髓内“反射”电路，介导的摄取和排斥或排斥行为。
The present study evaluates the central circuits that are synaptically engaged by very small subsets of the total population of geniculate ganglion cells to test the hypothesis that taste ganglion cells are heterogeneous in terms of their central connections. We used trans-synaptic anterograde pseudorabies virus labeling of fungiform taste papillae to infect single or small numbers of geniculate ganglion cells, together with the central neurons with which they connect, to define differential patterns of synaptically linked neurons in the taste pathway. Labeled brain cells were localized within known gustatory regions, including the rostral central subdivision (RC) of the nucleus of the solitary tract (NST), the principal site where geniculate axons synapse, and the site containing most of the cells that project to the parabrachial nucleus (PBN) of the pons. Cells were also located in the rostral lateral NST subdivision (RL), a site of trigeminal and sparse geniculate input, and the ventral NST (V) and medullary reticular formation (RF), a caudal brainstem pathway leading to reflexive oromotor functions. Comparisons among cases, each with a random, very small subset of labeled geniculate neurons, revealed “types” of central neural circuits consistent with a differential engagement of either the ascending or the local, intramedullary pathway by different classes of ganglion cells. We conclude that taste ganglion cells are heterogeneous in terms of their central connectivity, some engaging, predominantly, the ascending “lemniscal,” taste pathway, a circuit associated with higher order discriminative and homeostatic functions, others engaging the “local,” intramedullary “reflex” circuit that mediates ingestion and rejection oromotor behaviors.
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影响因子：
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通讯作者：
FISHMAN, IY
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