Ion channels and transporters in microglial function in physiology and brain diseases.
Ion channels and transporters in microglial function in physiology and brain diseases.
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DOI：
10.1016/j.neuint.2020.104925
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发表时间：
2021-01
影响因子：
4.2
通讯作者：
Sun D
中科院分区：
文献类型：
--
作者：
Luo L;Song S;Ezenwukwa CC;Jalali S;Sun B;Sun D
小胶质细胞与中枢神经系统 (CNS) 的所有组成部分相互作用，并且越来越多地认识到它们在大脑发育、体内平衡和疾病病理过程中发挥着重要作用。小胶质细胞的功能包括维持组织完整性、通过吞噬过程清除细胞碎片和死亡神经元，以及通过释放抗炎细胞因子和神经营养因子来提供组织修复。小胶质细胞离子稳态（Na+、Ca2+、K+、H+、Cl−）的变化对于小胶质细胞的活化非常重要，包括增殖、迁移、细胞因子释放和活性氧产生等。这些由小胶质细胞中的离子通道和离子转运蛋白介导。在这里，我们回顾了目前关于主要小胶质细胞离子通道和转运蛋白的作用的知识，包括几种类型的Ca2+通道（存储操纵的Ca2+进入（SOCE）通道、瞬时受体电位（TRP）通道和电压门控Ca2+通道（VGCC））和Na+通道（电压门控Na+通道（Nav）和酸感应离子通道（ASIC））、K+通道（内向整流器K+通道（Kir）、电压门控K+通道） (KV) 和钙激活 K+ 通道 (KCa))、质子通道（电压门控质子通道 (Hv1)）和 Cl− 通道（体积（或肿胀）调节的 Cl− 通道 (VRCC) 和氯细胞内通道 (CLIC)）。此外，Na+/Ca2+交换器（NCX）、Na+-K+-Cl−协同转运蛋白（NKCC1）和Na+/H+交换器（NHE1）等离子转运蛋白也参与生理和脑疾病中小胶质细胞的功能。我们讨论了脑疾病条件下与离子通道/转运蛋白刺激相关的小胶质细胞激活和神经炎症，以及针对神经退行性疾病、缺血性中风、创伤性脑损伤和神经性疼痛的小胶质细胞离子通道/转运蛋白的治疗方面。
Microglial cells interact with all components of the central nervous system (CNS) and are increasingly recognized to play essential roles during brain development, homeostasis and disease pathologies. Functions of microglia include maintaining tissue integrity, clearing cellular debris and dead neurons through the process of phagocytosis, and providing tissue repair by releasing anti-inflammatory cytokines and neurotrophic factors. Changes of microglial ionic homeostasis (Na+, Ca2+, K+, H+, Cl−) are important for microglial activation, including proliferation, migration, cytokine release and reactive oxygen species production, etc. These are mediated by ion channels and ion transporters in microglial cells. Here, we review the current knowledge about the role of major microglial ion channels and transporters, including several types of Ca2+ channels (store-operated Ca2+ entry (SOCE) channels, transient receptor potential (TRP) channels and voltage-gated Ca2+ channels (VGCCs)) and Na+ channels (voltage-gated Na+ channels (Nav) and acid-sensing ion channels (ASICs)), K+ channels (inward rectifier K+ channels (Kir), voltage-gated K+ channels (KV) and calcium-activated K+ channels (KCa)), proton channels (voltage-gated proton channel (Hv1)), and Cl− channels (volume (or swelling)-regulated Cl− channels (VRCCs) and chloride intracellular channels (CLICs)). In addition, ion transporter proteins such as Na+/Ca2+ exchanger (NCX), Na+-K+-Cl− cotransporter (NKCC1), and Na+/H+ exchanger (NHE1) are also involved in microglial function in physiology and brain diseases. We discussed microglial activation and neuroinflammation in relation to the ion channel/transporter stimulation under brain disease conditions and therapeutic aspects of targeting microglial ion channels/transporters for neurodegenerative disease, ischemic stroke, traumatic brain injury and neuropathic pain.
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影响因子：
5.6
作者：
Dolga AM;Culmsee C
通讯作者：
Culmsee C
影响因子：
5.8
作者：
Gonzalez, Carlos;Baez-Nieto, David;Latorre, Ramon
通讯作者：
Latorre, Ramon
影响因子：
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作者：
Harl, Barbara;Schmoelzer, Judith;Kerschbaum, Hubert H.
通讯作者：
Kerschbaum, Hubert H.
阻断 NHE1 可通过恢复骨髓细胞的 OXPHOS 功能来刺激神经胶质瘤肿瘤免疫。
影响因子：
12.4
作者：
Hasan MN;Luo L;Ding D;Song S;Bhuiyan MIH;Liu R;Foley LM;Guan X;Kohanbash G;Hitchens TK;Castro MG;Zhang Z;Sun D
通讯作者：
Sun D
影响因子：
8.3
作者：
Boscia, Francesca;Gala, Rosaria;Annunziato, Lucio
通讯作者：
Annunziato, Lucio