A novel HIV T helper epitope-based vaccine elicits cytokine-secreting HIV-specific CD4+ T cells in a Phase I clinical trial in HIV-uninfected adults.
A novel HIV T helper epitope-based vaccine elicits cytokine-secreting HIV-specific CD4+ T cells in a Phase I clinical trial in HIV-uninfected adults.
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DOI：
10.1016/j.vaccine.2009.09.060
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发表时间：
2009-11-23
期刊：
影响因子：
5.5
通讯作者：
NIAID HIV Vaccine Trials Network
中科院分区：
文献类型：
--
作者：
Jin X;Newman MJ;De-Rosa S;Cooper C;Thomas E;Keefer M;Fuchs J;Blattner W;Livingston BD;McKinney DM;Noonan E;Decamp A;Defawe OD;Wecker M;NIAID HIV Vaccine Trials Network
A Phase I human vaccine trial of a novel polypeptide vaccine of HIV T helper epitopes (EP-1043) and a DNA vaccine of HIV CTL epitopes was conducted in 84 healthy adult volunteers. The vaccine immunogenicity was assessed by an intracellular cytokine staining assay for IL-2, IL-4, TNFα and IFNγ. Sixty eight percent (32/47) of subjects had a positive CD4+ T response after receiving two vaccinations of the polypeptide vaccine. The responding CD4+ T cells made various combinations of IL-2, IL-4, IFN-γ, and TNF-α. The study demonstrated that the EP-1043 vaccine is safe, well-tolerated, and immunogenic.
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影响因子：
168.9
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Robertson, Michael N.
影响因子：
2.2
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影响因子：
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Vyakarnam, A
影响因子：
82.9
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通讯作者：
Seder, Robert A.
影响因子：
2.2
作者：
Perfetto, Stephen P.;Chattopadhyay, Pratip K.;Roederer, Mario
通讯作者：
Roederer, Mario