Phase changes in neuronal postsynaptic spiking due to short term plasticity.
Phase changes in neuronal postsynaptic spiking due to short term plasticity.
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DOI：
10.1371/journal.pcbi.1005634
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发表时间：
2017-09
影响因子：
4.3
通讯作者：
Graham BP
中科院分区：
文献类型：
--
作者：
McDonnell MD;Graham BP
在大脑中，神经元对时变输入的突触后反应由突触前尖峰时间与每个突触的短期动力学的相互作用决定。对于由随机突触驱动的神经元，突触抑制导致对大群体输入的完全不同的突触后响应，这取决于单个突触上的尖峰在时间上的相关性。在这里，我们使用模拟和数学分析表明，不仅速率，但突触后反应的相位的节奏人口输入变化作为一个函数的突触动力学和突触配置。所得到的相位超前可以补偿传输延迟并且预测节律变化。这对于神经系统中的感觉处理和运动节律的产生特别重要。连接大脑中神经元的突触远不是简单的中继点，将信号从一个神经元传递到另一个神经元。现在有很多证据表明，这种连接强度的长期变化决定了接收信号的幅度，支持大脑的学习和记忆。然而，信号幅度也在毫秒到秒的快速时间尺度上波动，这是由于调节神经递质从突触前末梢释放的各种特定的突触前机制。理解这种短期可塑性（STP）的信号滤波特性是一个挑战，需要理论模型。速率滤波和信息传输等方面进行了研究。在这里，我们探讨了STP对接收神经元对振荡输入的响应相位的影响，并表明短期抑郁可能导致频率依赖性相位领先。这对于处理有节奏的视觉和听觉信号以及产生有节奏的运动输出可能特别重要。
In the brain, the postsynaptic response of a neuron to time-varying inputs is determined by the interaction of presynaptic spike times with the short-term dynamics of each synapse. For a neuron driven by stochastic synapses, synaptic depression results in a quite different postsynaptic response to a large population input depending on how correlated in time the spikes across individual synapses are. Here we show using both simulations and mathematical analysis that not only the rate but the phase of the postsynaptic response to a rhythmic population input varies as a function of synaptic dynamics and synaptic configuration. Resultant phase leads may compensate for transmission delays and be predictive of rhythmic changes. This could be particularly important for sensory processing and motor rhythm generation in the nervous system. The synapses that connect neurons in the brain are far from being simple relay points that pass a signal from one neuron to another. There is now much evidence that long term changes in the strength of such connections, which determines the amplitude of the received signal, underpin learning and memory in the brain. However, signal amplitudes also fluctuate on fast time scales of milliseconds to seconds due to a variety of particular presynaptic mechanisms that regulate the release of neurotransmitter from the presynaptic terminal. Understanding the signal filtering properties of this short-term plasticity (STP) is a challenge and requires theoretical models. Aspects such as rate filtering and information transfer have been studied. Here we explore the effects of STP on the phase of a receiving neuron’s response to oscillating input and show that short-term depression can result in a frequency-dependent phase lead. This may be particularly important in the processing of rhythmic visual and auditory signals and producing rhythmic motor outputs.
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影响因子：
2.3
作者：
Akcay Z;Bose A;Nadim F
通讯作者：
Nadim F
DOI：
10.1007/s10162-002-2010-5
发表时间：
2003-03-01
影响因子：
2.4
作者：
Kopp-Scheinpflug, C;Lippe, WR;R端bsamen, R
通讯作者：
R端bsamen, R
影响因子：
3.2
作者：
McDonnell MD;Mohan A;Stricker C
通讯作者：
Stricker C
影响因子：
16.2
作者：
Bagnall, Martha W.;McElvain, Lauren E.;Faulstich, Michael;du Lac, Sascha
通讯作者：
du Lac, Sascha
影响因子：
3.2
作者：
Mohan A;McDonnell MD;Stricker C
通讯作者：
Stricker C