Interaction of short-term depression and firing dynamics in shaping single neuron encoding.
Interaction of short-term depression and firing dynamics in shaping single neuron encoding.
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DOI：
10.3389/fncom.2013.00041
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发表时间：
2013
影响因子：
3.2
通讯作者：
Stricker C
中科院分区：
文献类型：
--
作者：
Mohan A;McDonnell MD;Stricker C
我们研究了传入输入的短时突触抑制和突触后放电动力学这两个特性如何联合收割机起来决定神经元的工作模式。虽然几个计算角色已被归因于任何一个，他们的相互作用还没有被研究。我们考虑了两种类型的短期突触动力学（释放依赖性和释放独立性抑郁症）和两类发射动力学（定期发射和发射与尖峰频率适应）。的输入输出转换的前和突触后动力学的四种可能的组合进行了表征。从依赖释放的突触接收输入的适应神经元主要起着重合探测器的作用。其他三种构型显示出与积分器一致的性质，每种构型都具有不同的特征。这些结果表明，神经元的操作模式是由突触前和突触后动力学决定的，并且一起研究它们对于理解涌现特性及其对神经元编码的影响是必要的。
We investigated how the two properties short-term synaptic depression of afferent input and postsynaptic firing dynamics combine to determine the operating mode of a neuron. While several computational roles have been ascribed to either, their interaction has not been studied. We considered two types of short-term synaptic dynamics (release-dependent and release-independent depression) and two classes of firing dynamics (regular firing and firing with spike-frequency adaptation). The input–output transformation of the four possible combinations of pre- and post-synaptic dynamics was characterized. Adapting neurons receiving input from release-dependent synapses functioned largely as coincidence detectors. The other three configurations showed properties consistent with integrators, each with distinct features. These results suggest that the operating mode of a neuron is determined by both the pre- and post-synaptic dynamics and that studying them together is necessary to understand emergent properties and their implications for neuronal coding.
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影响因子：
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