Harnessing T Follicular Helper Cell Responses for HIV Vaccine Development.
Harnessing T Follicular Helper Cell Responses for HIV Vaccine Development.
复制标题
DOI：
10.3390/v10060336
复制
发表时间：
2018-06-19
期刊：
影响因子：
--
通讯作者：
Kaufmann DE
中科院分区：
文献类型：
--
作者：
Niessl J;Kaufmann DE
对非人灵长类动物被动施用能够识别广泛病毒株的广泛中和抗体（bNAb）已经导致保护免于嵌合SIV/HIV病毒（SHIV）的感染。这些数据表明，产生保护性抗体反应可能是艾滋病毒疫苗的有效策略。然而，迄今为止，经典的疫苗方法未能在HIV疫苗试验中诱导这种保护性抗体。在自然感染中鉴定的HIV特异性bNAb显示高水平的体细胞超突变，表明它们经历了广泛的亲和力成熟。为了获得识别不同病毒株的能力，疫苗诱导的体液应答也可能需要复杂的反复成熟。滤泡辅助性T细胞（Tfh）是一种特化的CD 4 + T细胞亚群，其为生发中心的B细胞提供帮助，以产生高亲和力和持久的体液应答。因此，疫苗接种后Tfh应答的质量和数量可能会影响bNAb的形成。在这里，我们回顾研究，提高我们的理解转铁蛋白的分化，功能和调节。我们讨论相关的转铁蛋白反应和bNAb的发展，在自然的HIV感染。最后，我们强调了最近的策略，以优化Tfh疫苗接种后的反应及其对预防性HIV疫苗研究的影响。
Passive administration of broadly neutralizing antibodies (bNAbs) capable of recognizing a broad range of viral strains to non-human primates has led to protection from infection with chimeric SIV/HIV virus (SHIV). This data suggests that generating protective antibody responses could be an effective strategy for an HIV vaccine. However, classic vaccine approaches have failed so far to induce such protective antibodies in HIV vaccine trials. HIV-specific bNAbs identified in natural infection show high levels of somatic hypermutations, demonstrating that they underwent extensive affinity maturation. It is likely that to gain ability to recognize diverse viral strains, vaccine-induced humoral responses will also require complex, iterative maturation. T follicular helper cells (Tfh) are a specialized CD4+ T cell subset that provides help to B cells in the germinal center for the generation of high-affinity and long-lasting humoral responses. It is therefore probable that the quality and quantity of Tfh responses upon vaccination will impact development of bNAbs. Here, we review studies that advanced our understanding of Tfh differentiation, function and regulation. We discuss correlates of Tfh responses and bNAb development in natural HIV infection. Finally, we highlight recent strategies to optimize Tfh responses upon vaccination and their impact on prophylactic HIV vaccine research.
登录
查看更多内容
影响因子：
82.9
作者：
通讯作者：
--
IL-18和囊下淋巴结巨噬细胞对于增强TLR4激动剂佐剂的B细胞反应至关重要。
DOI：
10.4049/jimmunol.1600993
发表时间：
2016-12-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Desbien AL;Dubois Cauwelaert N;Reed SJ;Bailor HR;Liang H;Carter D;Duthie MS;Fox CB;Reed SG;Orr MT
通讯作者：
Orr MT
影响因子：
32.4
作者：
Choi YS;Kageyama R;Eto D;Escobar TC;Johnston RJ;Monticelli L;Lao C;Crotty S
通讯作者：
Crotty S
影响因子：
30.5
作者：
Butler, Noah S.;Moebius, Jacqueline;Pewe, Lecia L.;Traore, Boubacar;Doumbo, Ogobara K.;Tygrett, Lorraine T.;Waldschmidt, Thomas J.;Crompton, Peter D.;Harty, John T.
通讯作者：
Harty, John T.
影响因子：
64.8
作者：
Crotty, S;Kersh, EN;Ahmed, R
通讯作者：
Ahmed, R