Antibodies that react with predetermined sites on proteins.
Antibodies that react with predetermined sites on proteins.
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与蛋白质上预定位点发生反应的抗体。
作者：
J. Sutcliffe;T. Shinnick;N. Green;R. Lerner
与之前的预测相反，模拟部分蛋白质序列的相对较短的合成肽通常能够引发与部分模拟的蛋白质发生反应的抗血清。能够引发蛋白质反应性血清的肽通常出现在蛋白质的一级序列中，可以通过一组简单的化学规则来表征，并且既不限于完整蛋白质的免疫显性区域，也不限于氨基或羧基末端。因此，合成肽免疫原对于产生具有预定特异性的可用于基础研究的试剂是有价值的。此外，一些合成肽能够模仿病毒蛋白区域，并在动物体内引发免疫反应，从而抵抗病毒。因此，此类肽可以作为安全的、化学成分确定的合成疫苗的基础。
Contrary to previous predictions, relatively short synthetic peptides that mimic part of a protein sequence are routinely capable of eliciting an antiserum that reacts with the partially mimicked protein. Peptides capable of eliciting protein-reactive serums are frequently represented in the primary sequence of a protein, can be characterized by a set of simple chemical rules, and are confined neither to immunodominant regions of intact proteins nor to the amino or carboxyl terminals. As such, synthetic peptide immunogens are valuable for eliciting reagents with predetermined specificity that can be used for basic research. In addition, some synthetic peptides are capable of mimicking regions of virus proteins and eliciting immune responses in animals that are protective against the viral agents. Such peptides may thus serve as the basis for safe, chemically defined synthetic vaccines.
多瘤病毒中型肿瘤抗原特异性抗体。
DOI：
10.1073/pnas.78.8.4882
发表时间：
1981
影响因子：
11.1
作者：
Walter,G;Hutchinson,MA;Hunter,T;Eckhart,W
通讯作者：
Eckhart,W
通过免疫亲和层析纯化多瘤病毒中等大小肿瘤抗原。
DOI：
10.1073/pnas.79.13.4025
发表时间：
1982
影响因子：
11.1
作者：
Walter,G;Hutchinson,MA;Hunter,T;Eckhart,W
通讯作者：
Eckhart,W