The global roadmap for advancing development of vaccines against sexually transmitted infections: Update and next steps.
The global roadmap for advancing development of vaccines against sexually transmitted infections: Update and next steps.
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DOI：
10.1016/j.vaccine.2016.03.111
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发表时间：
2016-06-03
期刊：
影响因子：
5.5
通讯作者：
Broutet N
中科院分区：
文献类型：
--
作者：
Gottlieb SL;Deal CD;Giersing B;Rees H;Bolan G;Johnston C;Timms P;Gray-Owen SD;Jerse AE;Cameron CE;Moorthy VS;Kiarie J;Broutet N
2014年，世界卫生组织、美国国立卫生研究院和全球技术合作伙伴发布了一份开发抗性传播感染新疫苗的全面路线图。自其出版以来，在若干路线图活动方面取得了进展：获得更好的流行病学数据，以确定性传播感染疫苗的公共卫生依据，对未来疫苗的理论影响进行建模，推进基础科学研究，确定第一代疫苗的首选产品特性，并鼓励对性传播感染疫苗开发进行投资。本文回顾了这些总体路线图活动，提供了针对单纯疱疹病毒、沙眼衣原体、淋病奈瑟菌和梅毒螺旋体的单个疫苗的研究和开发的最新情况，并讨论了推进性传播感染疫苗开发全球路线图的重要后续步骤。
In 2014, the World Health Organization, the US National Institutes of Health, and global technical partners published a comprehensive roadmap for development of new vaccines against sexually transmitted infections (STIs). Since its publication, progress has been made in several roadmap activities: obtaining better epidemiologic data to establish the public health rationale for STI vaccines, modeling the theoretical impact of future vaccines, advancing basic science research, defining preferred product characteristics for first-generation vaccines, and encouraging investment in STI vaccine development. This article reviews these overarching roadmap activities, provides updates on research and development of individual vaccines against herpes simplex virus, Chlamydia trachomatis, Neisseria gonorrhoeae, and Treponema pallidum, and discusses important next steps to advance the global roadmap for STI vaccine development.
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作者：
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