The impact of age-related changes on working memory functional activity.
The impact of age-related changes on working memory functional activity.
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DOI：
10.1007/s11682-008-9056-x
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发表时间：
2009
影响因子：
3.2
通讯作者：
Stern, Yaakov
中科院分区：
文献类型：
--
作者：
Steffener, Jason;Brickman, Adam M.;Rakitin, Brian C.;Gazes, Yunglin;Stern, Yaakov
本研究通过对年轻和老年参与者（年轻，N=37；平均年龄=25；老年人，N=15；平均年龄=74）的BOLD fMRI数据进行多变量分析，研究了年龄相关脑萎缩和功能性神经网络的关联。两个网络参与了在工作记忆中保留越来越多的口头信息。利用网络利用基于体素的形态测量法测试功能和灰质体积变化指数之间的关联。脑容量的整体变化与次级神经网络无关。初级网络内左侧中央前回区域灰质体积降低与次级网络利用率增加相关，与年龄组无关。区域灰质体积的减少仅在老年人中与年龄的增加有关。在老年人中，次级网络表达的增加与跨记忆负荷反应时间斜率的增加有关。这些结果支持了神经补偿理论，即老年参与者在面对与年龄相关的区域灰质体积减少时，需要额外的神经资源来维持任务表现。
This work investigated associations of age-related brain atrophy and functional neural networks identified using multivariate analyses of BOLD fMRI data in young and elder participants (young, N=37; mean age=25; elders, N=15; mean age=74). Two networks were involved in retaining increasing loads of verbal information in working memory. Network utilizations were used to test associations between function and indices of grey matter volume changes using voxel based morphometry. Global changes in brain volume were not associated with the secondary network. Lower regional grey matter volume in the left pre-central gyrus within the primary network was associated with increased secondary network utilization independent of age group. Decreased regional grey matter volume was associated with increased age only in the elders. Increased secondary network expression was associated with increased slope of reaction times across memory load, in the elders. These results support the theory of neural compensation, that elder participants recruit additional neural resources to maintain task performance in the face of age-related decreases in regional grey matter volume.
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DOI：
10.1016/j.cogbrainres.2004.10.010
发表时间：
2005-05-01
期刊：
COGNITIVE BRAIN RESEARCH
影响因子：
--
作者：
Habeck, C;Rakitin, BC;Stern, Y
通讯作者：
Stern, Y
影响因子：
3.7
作者：
Baltes, PB;Lindenberger, U
通讯作者：
Lindenberger, U
影响因子：
2.3
作者：
Altamura, Mario;Elvevag, Brita;Goldberg, Terry E.
通讯作者：
Goldberg, Terry E.
影响因子：
4.2
作者：
Busatto, GF;Garrido, GEJ;Bottino, CM
通讯作者：
Bottino, CM
影响因子：
16.2
作者：
Logan, JM;Sanders, AL;Buckner, RL
通讯作者：
Buckner, RL