Common and discrete mechanisms underlying chronic pain and itch: peripheral and central sensitization
Common and discrete mechanisms underlying chronic pain and itch: peripheral and central sensitization
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慢性疼痛和瘙痒的常见和离散机制：外周和中枢敏化
DOI：
10.1007/s00424-021-02599-y
复制
发表时间：
2021-07
期刊：
影响因子：
--
通讯作者：
Na Heung Sik
中科院分区：
文献类型：
--
作者：
Li Chengjin;Kim Hee Jin;Back Seung Keun;Na Heung Sik
正常情况下，疼痛和瘙痒之间存在明显的对抗性。在正常情况下，疼痛刺激会抑制瘙痒感觉，而止痛药通常会产生瘙痒。虽然疼痛和瘙痒在正常情况下是由不同的途径介导的，但在慢性病理条件下，大多数化学物质对一种感觉并不是高度特异的。值得注意的是，在神经性疼痛的患者中，组胺主要引起疼痛而不是瘙痒，而在特应性皮炎患者中，缓激肽引发的是瘙痒而不是疼痛。因此，在慢性瘙痒的情况下，反复抓挠甚至会增强瘙痒感觉。医生经常给慢性瘙痒患者开止痛药，这表明慢性疼痛和瘙痒的共同机制，特别是外周和中枢敏化。研究应该调查慢性瘙痒和疼痛，包括神经病变和炎症情况，而不是将瘙痒和疼痛分开。在这里，我们回顾了慢性致敏导致外周和中枢水平的慢性疼痛和瘙痒。研究疼痛和瘙痒之间的联系有助于在潜在的病理生理学基础上开发针对这两种慢性感觉障碍的新疗法。
Normally, an obvious antagonism exists between pain and itch. In normal conditions, painful stimuli suppress itch sensation, whereas pain killers often generate itch. Although pain and itch are mediated by separate pathways under normal conditions, most chemicals are not highly specific to one sensation in chronic pathologic conditions. Notably, in patients with neuropathic pain, histamine primarily induces pain rather than itch, while in patients with atopic dermatitis, bradykinin triggers itch rather than pain. Accordingly, repetitive scratching even enhances itch sensation in chronic itch conditions. Physicians often prescribe pain relievers to patients with chronic itch, suggesting common mechanisms underlying chronic pain and itch, especially peripheral and central sensitization. Rather than separating itch and pain, studies should investigate chronic itch and pain including neuropathic and inflammatory conditions. Here, we reviewed chronic sensitization leading to chronic pain and itch at both peripheral and central levels. Studies investigating the connection between pain and itch facilitate the development of new therapeutics against both chronic dysesthesias based on the underlying pathophysiology.
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DOI：
10.1523/jneurosci.5318-12.2013
发表时间：
2013-05-29
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
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作者：
Wilson SR;Nelson AM;Batia L;Morita T;Estandian D;Owens DM;Lumpkin EA;Bautista DM
通讯作者：
Bautista DM
影响因子：
2
作者：
R. Dmochowski
通讯作者：
R. Dmochowski
DOI：
10.1016/j.respe.2020.09.004
发表时间：
2020-10-10
期刊：
Revue D'Epidemiologie et De Sante Publique
影响因子：
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作者：
La rédaction
通讯作者：
La rédaction
影响因子：
9.3
作者：
通讯作者：
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