VEGF production and signaling in Müller glia are critical to modulating vascular function and neuronal integrity in diabetic retinopathy and hypoxic retinal vascular diseases.
VEGF production and signaling in Müller glia are critical to modulating vascular function and neuronal integrity in diabetic retinopathy and hypoxic retinal vascular diseases.
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DOI：
10.1016/j.visres.2017.05.005
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发表时间：
2017-10
期刊：
影响因子：
1.8
通讯作者：
Le YZ
中科院分区：
文献类型：
--
作者：
Le YZ
Müller胶质细胞（MG）是视网膜的主要支持细胞，参与视网膜的代谢、功能、维持和保护。在糖尿病视网膜病变（DR）（一种神经血管疾病和失明的主要原因）的发病过程中，MG通过调节血管生成因子和营养因子的产生来调节血管功能和神经元完整性。在这篇文章中，我将简要地总结我们的工作，描绘的作用和机制的MG调节血管功能，通过生产的血管内皮生长因子（VEGF）和调查VEGF信号介导的MG活力和神经保护在糖尿病动物模型，探讨VEGF和神经营养因子在体外糖尿病和缺氧模型中保护Müller细胞中的关系，以及其对糖尿病和缺氧的潜在意义。我们的工作与长期抗VEGF疗法的有效性和安全性相关，长期抗VEGF疗法是一种广泛用于对抗DR、糖尿病性黄斑水肿、新生血管性年龄相关性黄斑变性、早产儿视网膜病变和其他缺氧性视网膜血管疾病的策略。
Müller glia (MG) are major retinal supporting cells that participate in retinal metabolism, function, maintenance, and protection. During the pathogenesis of diabetic retinopathy (DR), a neurovascular disease and a leading cause of blindness, MG modulate vascular function and neuronal integrity by regulating the production of angiogenic and trophic factors. In this article, I will briefly summarize our work on delineating the role and mechanism of MG-modulated vascular function through the production of vascular endothelial growth factor (VEGF) and on investigating VEGF signaling-mediated MG viability and neural protection in diabetic animal models, explore the relationship among VEGF and neurotrophins in protecting Müller cells in in vitro models of diabetes and hypoxia and its potential implication to neuroprotection in DR and hypoxic retinal diseases, and discuss the relevance of our work to the effectiveness and safety of long-term anti-VEGF therapies, a widely used strategy to combat DR, diabetic macular edema, neovascular age-related macular degeneration, retinopathy of prematurity, and other hypoxic retinal vascular disorders.
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影响因子：
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作者：
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