Topical delivery of mesenchymal stem cells and their function in wounds.
Topical delivery of mesenchymal stem cells and their function in wounds.
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DOI：
10.1186/scrt30
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发表时间：
2010-09-24
影响因子：
7.5
通讯作者：
Caplan AI
中科院分区：
文献类型：
--
作者：
Sorrell JM;Caplan AI
间充质干细胞是在大多数成人器官中发现的成纤维细胞样细胞的异质群体。然而，我们目前的知识大多是基于骨髓或间质脂肪组织的细胞。这些细胞能够沿沿着各种间充质谱系分化。此外，它们已在伤口和缺血情况下表现出治疗特性。这些细胞的治疗特性在它们进入伤口或其他受损组织时被激活。目前的问题是开发确保这些细胞以及时的方式和足够的数量到达伤口床以最大化其治疗益处的策略。目前，有两种基本的递送方法：将细胞全身输注到血管循环中和将治疗性细胞直接应用于伤口部位。皮肤伤口是局部递送方法的最佳候选者。然而，将治疗性细胞递送至此类伤口的方法各不相同。本文概述了用于将治疗性细胞递送到皮肤和其他伤口的基本方法。在进入伤口后，治疗性细胞通过尚不清楚的旁分泌机制与其他伤口细胞相互作用。尽管如此，与血管内皮细胞的相互作用和免疫调节似乎在加速伤口愈合和在愈合过程完成后减少瘢痕形成方面发挥重要作用。虽然现象学的证据表明治疗细胞的功效是实质性的，但仍然需要大量的工作来更好地确定这些细胞的分子和细胞功能，并评估它们的命运和它们的应用的长期后果。
Mesenchymal stem cells are a heterogeneous population of fibroblast-like cells found in most adult organs. However, most of our current knowledge is based on cells of bone marrow or interstitial adipose tissues. These cells are capable of differentiation along various mesenchymal lineages. In addition, they have demonstrated therapeutic characteristics in wounds and ischemic situations. The therapeutic characteristics of these cells are activated upon their entering wounds or other damaged tissues. A current problem is the development of strategies that ensure that these cells reach wound beds in a timely fashion and in sufficient numbers to maximize their therapeutic benefits. Currently, there are two basic delivery methods: systemic infusion of cells into the vascular circulation and direct application of therapeutic cells to wound sites. Skin wounds are optimal candidates for the topical delivery approach. However, the methods by which therapeutic cells are delivered to such wounds vary. This review outlines the basic methods used to deliver therapeutic cells to skin and other wounds. Upon entering wounds, therapeutic cells interact with other wound cells through paracrine mechanisms that are not yet well understood. Nonetheless, interactions with vascular endothelial cells and immunomodulation appear to play significant roles in accelerating wound healing and in reducing scar formation upon the completion of the healing process. Although the phenomenological body of evidence indicating the efficacy of therapeutic cells is substantial, considerable work is still required to better determine the molecular and cellular functions of these cells and to assess their fate and the long-term consequences of their application.
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影响因子：
3.6
作者：
Hamou C;Callaghan MJ;Thangarajah H;Chang E;Chang EI;Grogan RH;Paterno J;Vial IN;Jazayeri L;Gurtner GC
通讯作者：
Gurtner GC
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2.6
作者：
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3.3
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通讯作者：
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影响因子：
4
作者：
Caplan, Arnold I.;Dennis, James E.
通讯作者：
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影响因子：
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作者：
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通讯作者：
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