CHEMICAL CHARACTERIZATION OF AN IMMOBILIZED HEPARIN: HEPARIN-PVA
CHEMICAL CHARACTERIZATION OF AN IMMOBILIZED HEPARIN: HEPARIN-PVA
复制标题
固定化肝素的化学特性：肝素-PVA
DOI：
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发表时间：
1984
期刊：
影响因子：
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通讯作者：
M. Sefton
中科院分区：
文献类型：
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作者：
C. H. Cholakis;M. Sefton
肝素化的polymers1，2，无论是离子或共价键，已被用于不同程度的成功赋予材料的抗血栓性的技术之一。例如，肝素与聚乙烯醇（PVA）的共价偶联产生了肝素-PVA水凝胶，在没有显著肝素释放的情况下，该水凝胶似乎在体外保持血液相容性3，4。本文的目的是报告肝素-PVA水凝胶在肝素含量和偶联点方面的化学表征。肝素的复杂性和异质性使得这对于这种或任何肝素化生物材料来说都是一项困难的任务。
Heparinization of polymers1,2, either ionically or covalently, has been one of the techniques used with varying degrees of success to impart thromboresistance to materials. For example, the covalent coupling of heparin to polyvinyl alcohol (PVA) has resulted in a heparin-PVA hydrogel which appears to retain blood compatibility in vitro3,4, in the absence of significant heparin release. It is the aim of this paper to report on the chemical characterization of the heparin-PVA hydrogel in terms of heparin content and point of coupling. The complexity and heterogenity of heparin make this a difficult task for this or any heparinized biomaterial.
DOI：
10.1002/jbm.820170212
发表时间：
1983-01-01
期刊：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
影响因子：
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作者：
GOOSEN, MFA;SEFTON, MV
通讯作者：
SEFTON, MV
DOI：
10.1002/jbm.820170310
发表时间：
1983-01-01
期刊：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
影响因子：
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作者：
BASMADJIAN, D;SEFTON, MV
通讯作者：
SEFTON, MV