Denuded subchondral bone and knee pain in persons with knee osteoarthritis.
Denuded subchondral bone and knee pain in persons with knee osteoarthritis.
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DOI：
10.1002/art.25014
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发表时间：
2009-12
影响因子：
--
通讯作者：
Sharma, Leena
中科院分区：
文献类型：
--
作者：
Moisio, Kirsten;Eckstein, Felix;Chmiel, Joan S.;Guermazi, Ali;Prasad, Pottumarthi;Almagor, Orit;Song, Jing;Dunlop, Dorothy;Hudelmaier, Martin;Kothari, Ami;Sharma, Leena
关节软骨损失如何导致膝关节OA患者的疼痛尚不清楚。全层软骨缺损暴露软骨下骨板。裸露的骨骼和疼痛之间的关系尚未得到研究。我们研究了%裸露骨是否与中重度膝关节疼痛或频繁膝关节疼痛相关;以及基线评估后两年内与频繁膝关节疼痛事件的纵向相关性。我们研究了182例膝关节OA患者（305个膝关节）。应用专门的MRI技术，手动分割用于计算每个表面的软骨覆盖和裸露骨面积。中重度膝关节疼痛定义为膝关节特定100 mm VAS ≥40 mm，频繁膝关节疼痛定义为过去一个月内大部分时间疼痛。Logistic回归和GEE用于校正年龄、性别、BMI和骨髓病变的分析。横断面分析显示，中重度膝关节疼痛与内侧间室（调整OR 3.90，95% CI 1.33，11.47）、内侧和髌骨表面以及外侧和髌骨表面的裸露骨百分比相关。频繁的膝关节疼痛与髌骨表面（调整OR 3.11，95% CI 1.24，7.81）、内侧和髌骨表面以及外侧和髌骨表面的裸露骨%相关。纵向分析（168例基线时无频繁膝关节疼痛的膝关节）显示，内侧和髌骨表面的裸露骨与频繁膝关节疼痛事件相关（调整后OR 4.19，95% CI 1.56，11.22）。这些结果支持软骨下骨板暴露与膝关节OA患者的普遍和偶发膝关节疼痛之间的关系。
How articular cartilage loss contributes to pain in persons with knee OA is unclear. Full thickness cartilage defects expose the subchondral bone plate. The relationship between denuded bone and pain has not been examined. We studied whether %denuded bone is associated: with moderate-severe knee pain or frequent knee pain; and longitudinally with incident frequent knee pain two years after the baseline evaluation. We studied 182 persons with knee OA (305 knees). Applying specialized MRI techniques, manual segmentation was used to compute cartilage-covered and denuded bone areas for each surface. Moderate-severe knee pain was defined as ≥40 mm on knee-specific 100 mm VASs, and frequent knee pain as pain for most days in the past month. Logistic regression and GEE were used in analyses adjusting for age, gender, BMI, and bone marrow lesions. Cross-sectional analyses revealed that moderate-severe knee pain was associated with %denuded bone in the medial compartment (adjusted OR 3.90, 95% CI 1.33, 11.47), medial and patellar surfaces together, and lateral and patellar surfaces. Frequent knee pain was associated with %denuded bone in the patellar surface (adjusted OR 3.11, 95% CI 1.24, 7.81), medial and patellar surfaces, and lateral and patellar surfaces. Longitudinal analyses (in 168 knees without baseline frequent knee pain) revealed that denuded bone in medial and patellar surfaces was associated with incident frequent knee pain (adjusted OR 4.19, 95% CI 1.56, 11.22). These results support a relationship between subchondral bone plate exposure and prevalent and incident knee pain in persons with knee OA.
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影响因子：
7
作者：
Torres, L.;Dunlop, D. D.;Sharma, L.
通讯作者：
Sharma, L.
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