Protein P4 of the bacteriophage phi 6 procapsid has a nucleoside triphosphate-binding site with associated nucleoside triphosphate phosphohydrolase activity
Protein P4 of the bacteriophage phi 6 procapsid has a nucleoside triphosphate-binding site with associated nucleoside triphosphate phosphohydrolase activity
复制标题
噬菌体 phi 6 原衣壳的蛋白 P4 具有核苷三磷酸结合位点，具有相关的核苷三磷酸磷酸水解酶活性
作者：
P. Gottlieb;J. Strassman;L. Mindich
噬菌体phi 6含有三个双链RNA片段。原衣壳由蛋白质P1、P2、P4和P7组成，它们由病毒L片段编码。该片段的cDNA拷贝已被克隆到质粒中，质粒指导这些蛋白质的产生，这些蛋白质组装成多面体原衣壳。这些原衣壳能够在三磷酸核苷存在下包装正义phi 6 RNA并合成互补负链以形成双链RNA。在这篇文章中，我们报告的存在下，一个核苷酸结合位点的蛋白质P4。病毒原衣壳和核衣壳表现出将核苷三磷酸转化为核苷二磷酸的核苷三磷酸磷酸水解酶活性。
Bacteriophage phi 6 contains three segments of double-stranded RNA. The procapsid consists of proteins P1, P2, P4, and P7, which are encoded by the viral L segment. cDNA copies of this segment have been cloned into plasmids that direct the production of these proteins, which assemble into polyhedral procapsids. These procapsids are capable of packaging plus-sense phi 6 RNA in the presence of nucleoside triphosphate and synthesizing the complementary minus strand to form double-stranded RNA. In this article, we report the presence of a nucleotide-binding site in protein P4. The viral procapsid and nucleocapsid exhibit a nucleoside triphosphate phosphohydrolase activity that converts nucleoside triphosphates into nucleoside diphosphates.
影响因子：
5.6
作者：
GUO, PX;PETERSON, C;ANDERSON, D
通讯作者：
ANDERSON, D