Effect of aspirin and non-steroidal anti-inflammatory drugs on colorectal adenomas: case-control study of subjects participating in the Nottingham faecal occult blood screening programme.
Effect of aspirin and non-steroidal anti-inflammatory drugs on colorectal adenomas: case-control study of subjects participating in the Nottingham faecal occult blood screening programme.
复制标题
阿司匹林和非甾体抗炎药对结直肠腺瘤的影响：参与诺丁汉粪便潜血筛查项目的受试者的病例对照研究。
作者：
R. Logan;J. Little;P. Hawtin;J. Hardcastle
目的--研究阿司匹林和非类固醇抗炎药的使用与无症状结直肠腺瘤的关系。设计--病例对照研究，受试者参加大便隐血筛查结直肠癌的随机对照试验。关于镇痛剂和其他药物的数据是从一份主要与饮食有关的问卷中获得的，该问卷由一名面试者管理。背景--诺丁汉。受试者--147名粪便潜血试验阳性的患者被发现患有结直肠腺瘤(病例)，153名年龄和性别匹配的对照组(阴性对照组)，以及176名检测呈阳性的对照组(阳性对照组)，他们被发现没有结直肠腺瘤。主要观察指标--根据镇痛剂的使用频率和持续时间，发生结直肠腺瘤的相对风险。结果--病例报告服用阿司匹林和非类固醇抗炎药比阴性对照少，估计使用任何药物的相对风险为0.49(95%可信区间为0.3至0.8)。当病例与阳性对照相比(0.66(0.4至1.1))时，这种反向关联不那么强烈。这种联系是阿司匹林和非类固醇抗炎药特有的，与扑热息痛或其他药物无关。处方使用非类固醇抗炎药物超过五年的风险最低(0.21(0.1至0.8))，尽管报告长期使用非类固醇抗炎药物的人数很少。结论--这些发现支持阿司匹林和非类固醇消炎药的使用可以预防大肠肿瘤发展的假说。
OBJECTIVE--To examine the relation between the use of aspirin and non-steroidal anti-inflammatory drugs and the presence of asymptomatic colorectal adenomas. DESIGN--Case-control study of subjects participating in a randomised controlled trial of faecal occult blood screening for colorectal cancer. Data on analgesics and other drugs were obtained from a questionnaire which was mainly concerned with diet and was administered by an interviewer. SETTING--Nottingham. SUBJECTS--147 patients with positive results in faecal occult blood tests who were found to have colorectal adenomas (cases), 153 age and sex matched control subjects with negative results in such tests (negative controls), and 176 control subjects with positive results in the tests who were found not to have colorectal adenomas (positive controls). MAIN OUTCOME MEASURES--Relative risk of developing colorectal adenomas according to frequency and duration of use of analgesics. RESULTS--Cases reported taking less aspirin and non-steroidal anti-inflammatory drugs than the negative controls, with the estimated relative risk for any use being 0.49 (95% confidence interval 0.3 to 0.8). The inverse association was less strong when cases were compared with the positive controls (0.66 (0.4 to 1.1)). The association was specific for aspirin and non-steroidal anti-inflammatory drugs there being no association with paracetamol or other drugs. Prescribed use of non-steroidal anti-inflammatory drugs for longer than five years was associated with the lowest risk (0.21 (0.1 to 0.8)), although the numbers reporting prolonged prescribed use were small. CONCLUSIONS--These findings support the hypothesis that aspirin and non-steroidal anti-inflammatory drug use protects against the development of colorectal neoplasia.
在大鼠结肠肿瘤发展的不同阶段，膳食吡罗昔康（一种非甾体抗炎药）对结肠癌发生的剂量相关抑制作用。
影响因子：
11.2
作者：
Reddy,BS;Maruyama,H;Kelloff,G
通讯作者：
Kelloff,G
DOI：
10.1093/jnci/83.5.355
发表时间：
1991-03-06
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
ROSENBERG, L;PALMER, JR;SHAPIRO, S
通讯作者：
SHAPIRO, S