The Role of Dendritic Cell Subsets and Innate Immunity in the Pathogenesis of Type 1 Diabetes and Other Autoimmune Diseases.
The Role of Dendritic Cell Subsets and Innate Immunity in the Pathogenesis of Type 1 Diabetes and Other Autoimmune Diseases.
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DOI：
10.3389/fimmu.2015.00288
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发表时间：
2015
影响因子：
7.3
通讯作者：
Tarbell KV
中科院分区：
文献类型：
--
作者：
Price JD;Tarbell KV
树突状细胞（DC）是关键的抗原呈递细胞，在自身免疫发病机制中发挥重要作用。 DC 控制稳态 T 细胞耐受性和致病反应的激活。这两种结果之间的平衡取决于多种因素，包括遗传易感性、刺激各种先天反应的环境信号以及哪个 DC 亚群呈递抗原。尽管特定的 DC 表型可能会根据组织位置和环境而有所不同，但在小鼠和人类中均发现了四个主要子集：传统的 cDC1 和 cDC2、浆细胞样 DC 和单核细胞衍生的 DC。在这篇综述中，我们将讨论这些亚群在自身免疫发病机制和调节中的作用，以及影响其功能的遗传和环境信号。需要讨论的具体主题包括易感位点对 DC 亚群的影响、DC 亚群发育的改变、感染和宿主衍生的先天炎症信号的作用以及肠道微生物群对 DC 表型的作用。将检查这些不同信号对疾病进展的影响以及DC子集组成和DC成熟水平的相对影响。我们将使用几种自身免疫性疾病的例子来探索这些领域，但主要关注 1 型糖尿病。
Dendritic cells (DCs) are key antigen-presenting cells that have an important role in autoimmune pathogenesis. DCs control both steady-state T cell tolerance and activation of pathogenic responses. The balance between these two outcomes depends on several factors, including genetic susceptibility, environmental signals that stimulate varied innate responses, and which DC subset is presenting antigen. Although the specific DC phenotype can diverge depending on the tissue location and context, there are four main subsets identified in both mouse and human: conventional cDC1 and cDC2, plasmacytoid DCs, and monocyte-derived DCs. In this review, we will discuss the role of these subsets in autoimmune pathogenesis and regulation, as well as the genetic and environmental signals that influence their function. Specific topics to be addressed include impact of susceptibility loci on DC subsets, alterations in DC subset development, the role of infection- and host-derived innate inflammatory signals, and the role of the intestinal microbiota on DC phenotype. The effects of these various signals on disease progression and the relative effects of DC subset composition and maturation level of DCs will be examined. These areas will be explored using examples from several autoimmune diseases but will focus mainly on type 1 diabetes.
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影响因子：
15.3
作者：
Bonifaz, L;Bonnyay, D;Mahnke, K;Rivera, M;Nussenzweig, MC;Steinman, RM
通讯作者：
Steinman, RM
DOI：
10.1084/jem.20131397
发表时间：
2014-08-25
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Anandasabapathy N;Feder R;Mollah S;Tse SW;Longhi MP;Mehandru S;Matos I;Cheong C;Ruane D;Brane L;Teixeira A;Dobrin J;Mizenina O;Park CG;Meredith M;Clausen BE;Nussenzweig MC;Steinman RM
通讯作者：
Steinman RM
影响因子：
4.4
作者：
Bourges, Dorothee;Ross, Ellen M.;van Driel, Ian R.
通讯作者：
van Driel, Ian R.
影响因子：
7.7
作者：
Chilton, PM;Rezzoug, F;Ildstad, ST
通讯作者：
Ildstad, ST
影响因子：
3.7
作者：
Carrero JA;Calderon B;Towfic F;Artyomov MN;Unanue ER
通讯作者：
Unanue ER