Intermittent hypoxia, respiratory plasticity and sleep apnea in humans: present knowledge and future investigations.
Intermittent hypoxia, respiratory plasticity and sleep apnea in humans: present knowledge and future investigations.
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DOI：
10.1016/j.resp.2013.04.010
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发表时间：
2013-09-15
影响因子：
2.3
通讯作者：
Syed, Ziauddin
中科院分区：
文献类型：
--
作者：
Mateika, Jason H.;Syed, Ziauddin
关键词：
本综述探讨了呼吸可塑性在睡眠呼吸暂停患者睡眠期间维持呼吸稳定性方面的作用。综述的第一部分考虑了睡眠呼吸暂停患者可能发起重复呼吸事件的方式。此后，研究了两种形式的呼吸可塑性，即缺氧通气反应的逐渐增强以及上呼吸道和呼吸肌活动的长期促进，可能在改变人类呼吸事件中的作用。在这种情况下，目前关于人类在清醒和睡眠期间呼吸可塑性启动的知识得到了解决。此外，已发表的研究结果表明，暴露于间歇性缺氧会促进呼吸不稳定，至少部分原因是缺氧通气反应逐渐增强，并且缺乏长期促进作用。接下来，提出了未来的方向，并重点关注如何促进稳定呼吸的可塑性形式，同时减少不稳定形式。这些未来的方向将考虑昼夜节律在促进呼吸可塑性方面的潜在作用，以及呼吸可塑性在增强现有的睡眠呼吸暂停治疗方法中的作用。
This review examines the role that respiratory plasticity has in the maintenance of breathing stability during sleep in individuals with sleep apnea. The initial portion of the review considers the manner in which repetitive breathing events may be initiated in individuals with sleep apnea. Thereafter, the role that two forms of respiratory plasticity, progressive augmentation of the hypoxic ventilatory response and long-term facilitation of upper airway and respiratory muscle activity, might have in modifying breathing events in humans is examined. In this context, present knowledge regarding the initiation of respiratory plasticity in humans during wakefulness and sleep is addressed. Also, published findings which reveal that exposure to intermittent hypoxia promotes breathing instability, at least in part, because of progressive augmentation of the hypoxic ventilatory response and the absence of long-term facilitation, are considered. Next, future directions are presented and are focused on the manner in which forms of plasticity that stabilize breathing might be promoted while diminishing destabilizing forms, concurrently. These future directions will consider the potential role of circadian rhythms in the promotion of respiratory plasticity and the role of respiratory plasticity in enhancing established treatments for sleep apnea.
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影响因子：
3.3
作者：
Gerst, David G., III;Yokhana, Sanar S.;Mateika, Jason H.
通讯作者：
Mateika, Jason H.
影响因子：
3.3
作者：
Chowdhuri, Susmita;Shanidze, Irina;Badr, M. Safwan
通讯作者：
Badr, M. Safwan
影响因子：
5.5
作者：
Griffin, Harry S.;Pugh, Keith;Balanos, George M.
通讯作者：
Balanos, George M.
影响因子：
2.3
作者：
Bradford, A;McGuire, M;O'Halloran, KD
通讯作者：
O'Halloran, KD
DOI：
10.1046/j.1440-1843.1999.00163.x
发表时间：
1999-06-01
期刊：
Respirology (Carlton, Vic.)
影响因子：
--
作者：
Fuse, K;Satoh, M;Arakawa, M
通讯作者：
Arakawa, M