The pharmacology and molecular mechanisms underlying temperature regulation and torpor.
The pharmacology and molecular mechanisms underlying temperature regulation and torpor.
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DOI：
10.1016/j.bcp.2008.06.017
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发表时间：
2008-10-01
影响因子：
5.8
通讯作者：
Swoap, Steven J.
中科院分区：
文献类型：
--
作者：
Swoap, Steven J.
在限制热量摄入后进入低代谢状态的能力对于动物生存至关重要：当食物不可用时和/或维持恒温的产热需求变得过度时，平衡吸热动物的能量预算可能是一场真实的斗争。在动物界的许多生物体中，包括那些可以被描述为典型实验室动物的生物体，如小鼠或仓鼠，都会出现以代谢率远低于基础代谢率和核心体温可能仅高于环境温度几度为特征的间歇性麻痹。日常的异温动物，这是这篇评论的重点，进入浅麻痹发作，这样做通常在严重的食物短缺条件和相对凉爽的环境。由于它们的体型小，这些动物的体温对食物剥夺、代谢率的药物抑制和心血管抑制剂非常敏感。这篇评论探讨了最近的事态发展有关的神经内分泌机制的地方，可能会调解禁食引起的麻木，在日常的异温动物。此外，这篇评论强调了小哺乳动物低温的药理学诱导。
The ability to enter a hypometabolic state upon restriction of caloric intake is pivotal for animal survival: balancing the energy budget in endotherms can be a real struggle when food is not available and/or the demand for heat production to maintain homeothermy becomes excessive. Bouts of torpor, characterized by metabolic rates well below a basal metabolic rate and core body temperatures that may be just a few degrees above the ambient temperature, are utilized among many organisms across the animal kingdom, including those that could be described as typical laboratory animals, like the mouse or hamster. Daily heterotherms, which are the focus of this commentary, enter shallow torpor bouts and do so usually under acute food shortage conditions and a relatively cool environment. Due to their small size, the body temperature of these animals is very responsive to food deprivation, pharmacological inhibition of metabolic rate, and cardiovascular depressants. This commentary examines recent developments concerning the neuroendocrine mechanisms in place that may mediate fasting-induced torpor in daily heterotherms. Further this commentary highlights pharmacological induction of hypothermia in small mammals.
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影响因子：
29.4
作者：
Date, Y;Murakami, N;Nakazato, M
通讯作者：
Nakazato, M
影响因子：
16.2
作者：
Cowley, MA;Smith, RG;Horvath, TL
通讯作者：
Horvath, TL
影响因子：
4.8
作者：
Chiellini, Grazia;Frascarelli, Sabina;Zucchi, Riccardo
通讯作者：
Zucchi, Riccardo
DOI：
10.1016/0010-406x(70)90492-5
发表时间：
1970-01-01
期刊：
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY
影响因子：
--
作者：
HAYDEN, P;LINDBERG, RG
通讯作者：
LINDBERG, RG
影响因子：
56.9
作者：
Blackstone, E;Morrison, M;Roth, MB
通讯作者：
Roth, MB