Association analysis of 31 common polymorphisms with type 2 diabetes and its related traits in Indian sib pairs.
Association analysis of 31 common polymorphisms with type 2 diabetes and its related traits in Indian sib pairs.
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DOI：
10.1007/s00125-011-2355-6
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发表时间：
2012-02
期刊：
影响因子：
8.2
通讯作者：
Chandak, G. R.
中科院分区：
文献类型：
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作者：
Gupta, V.;Vinay, D. G.;Rafiq, S.;Kranthikumar, M. V.;Janipalli, C. S.;Giambartolomei, C.;Evans, D. M.;Mani, K. R.;Sandeep, M. N.;Taylor, A. E.;Kinra, S.;Sullivan, R. M.;Bowen, L.;Timpson, N. J.;Smith, G. D.;Dudbridge, F.;Prabhakaran, D.;Ben-Shlomo, Y.;Reddy, K. S.;Ebrahim, S.;Chandak, G. R.
在印度人群中评估31种常见单核苷酸多态性（SNP）与空腹血糖、空腹胰岛素、HOMA-β细胞功能（HOMA-β）、HOMA-胰岛素抵抗（HOMA-IR）和2型糖尿病的相关性我们对来自印度四个城市（勒克瑙、纳格布尔、海得拉巴和班加罗尔）的3,089对同胞进行了基因分型，检测了先前与欧洲人群2型糖尿病相关的24个基因中的31个SNP。我们对2型糖尿病及其相关数量性状进行了同胞内配对分析。所有SNP的风险等位基因频率与西方人群中报道的频率相当。我们证明了CXCR 4与（rs932206），CDKAL1（rs7756992）和TCF 7 L2（rs7903146，rs 12255372）空腹血糖，β值为0.007（p = 0.05）、0.01（p = 0.01）、0.007（p = 0.05）、0.01（p = 0.003）和0.08（p = 0.01）。NOTCH 2的变体（rs10923931），TCF-2（也称为HNF 1B）（rs757210），ADAM 30（rs 2641348）和CDKN 2 A/B（rs 10811661）显著预测空腹胰岛素，β值分别为-0.06（p = 0.04）、0.05（p = 0.05）、-0.08（p = 0.01）和-0.08（p = 0.02）。对于HOMA-IR，我们检测到与TCF-2、ADAM 30和CDKN 2A/B相关，β值分别为0.05（p = 0.04）、-0.07（p = 0.03）和-0.08（p = 0.02）。我们还发现ADAM 30（β =-0.05; p = 0.01）和CDKN 2 A/B（β =-0.05; p = 0.03）与HOMA-β显著相关。THADA变异体（rs7578597）与2型糖尿病相关（OR 1.5; 95% CI 1.04，2.22; p = 0.03）。我们验证了关联的7个已建立的基因座与中间性状相关的2型糖尿病在印度人口中使用的设计抵抗人口分层。本文的在线版本（doi：10.1007/s 00125 -011-2355-6）包含同行评审但未经编辑的补充材料，可供授权用户使用。
Evaluation of the association of 31 common single nucleotide polymorphisms (SNPs) with fasting glucose, fasting insulin, HOMA-beta cell function (HOMA-β), HOMA-insulin resistance (HOMA-IR) and type 2 diabetes in the Indian population. We genotyped 3,089 sib pairs recruited in the Indian Migration Study from four cities in India (Lucknow, Nagpur, Hyderabad and Bangalore) for 31 SNPs in 24 genes previously associated with type 2 diabetes in European populations. We conducted within-sib-pair analysis for type 2 diabetes and its related quantitative traits. The risk-allele frequencies of all the SNPs were comparable with those reported in western populations. We demonstrated significant associations of CXCR4 (rs932206), CDKAL1 (rs7756992) and TCF7L2 (rs7903146, rs12255372) with fasting glucose, with β values of 0.007 (p = 0.05), 0.01 (p = 0.01), 0.007 (p = 0.05), 0.01 (p = 0.003) and 0.08 (p = 0.01), respectively. Variants in NOTCH2 (rs10923931), TCF-2 (also known as HNF1B) (rs757210), ADAM30 (rs2641348) and CDKN2A/B (rs10811661) significantly predicted fasting insulin, with β values of −0.06 (p = 0.04), 0.05 (p = 0.05), −0.08 (p = 0.01) and −0.08 (p = 0.02), respectively. For HOMA-IR, we detected associations with TCF-2, ADAM30 and CDKN2A/B, with β values of 0.05 (p = 0.04), −0.07 (p = 0.03) and −0.08 (p = 0.02), respectively. We also found significant associations of ADAM30 (β = −0.05; p = 0.01) and CDKN2A/B (β = −0.05; p = 0.03) with HOMA-β. THADA variant (rs7578597) was associated with type 2 diabetes (OR 1.5; 95% CI 1.04, 2.22; p = 0.03). We validated the association of seven established loci with intermediate traits related to type 2 diabetes in an Indian population using a design resistant to population stratification. The online version of this article (doi:10.1007/s00125-011-2355-6) contains peer-reviewed but unedited supplementary material, which is available to authorised users.
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DOI：
10.1016/j.tig.2008.09.004
发表时间：
2008-12
期刊：
Trends in genetics : TIG
影响因子：
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作者：
Prokopenko I;McCarthy MI;Lindgren CM
通讯作者：
Lindgren CM
DOI：
10.1038/nrg2544
发表时间：
2009-05
期刊：
Nature reviews. Genetics
影响因子：
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作者：
Ioannidis JP;Thomas G;Daly MJ
通讯作者：
Daly MJ
影响因子：
30.8
作者：
通讯作者：
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影响因子：
9.8
作者：
Abecasis, GR;Cardon, LR;Cookson, WOC
通讯作者：
Cookson, WOC
影响因子：
64.8
作者：
通讯作者：
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