Circular RNA CircPPP1CB Suppresses Tumorigenesis by Interacting With the MiR-1307-3p/SMG1 Axis in Human Bladder Cancer.
Circular RNA CircPPP1CB Suppresses Tumorigenesis by Interacting With the MiR-1307-3p/SMG1 Axis in Human Bladder Cancer.
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环状 RNA CircPPP1CB 通过与人膀胱癌中的 MiR-1307-3p/SMG1 轴相互作用来抑制肿瘤发生
DOI：
10.3389/fcell.2021.704683
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发表时间：
2021
影响因子：
5.5
通讯作者：
Jin X
中科院分区：
文献类型：
--
作者：
Wang F;Zhang Y;Zhou X;Chen X;Xiang J;Fan M;Yu Y;Cai Y;Wu H;Huang S;He N;Hu Z;Ding G;Jin X
环状RNA（circular RNA）是一种新发现的内源性非编码RNA（ncRNA），具有封闭的环状结构。越来越多的证据证实了circRNA在人类癌症中的重要作用。本研究选择人膀胱癌（BC）中的circPPP 1CB作为研究对象，通过circRNA测序和实时定量PCR（qRT-PCR）验证。CircPPP 1CB在BC中表达下调，且与临床分期和组织学分级呈负相关。在功能上，circPPP 1CB在体外和体内调节细胞生长、转移和上皮向间充质转化（EMT）过程。在机械方面，我们进行了各种实验来验证circPPP 1CB/miR-1307- 3 p/SMG 1调节轴。综上所述，我们的结果表明，circPPP 1CB通过与miR-1307- 3 p/SMG 1轴相互作用参与肿瘤生长、转移和EMT过程，并且circPPP 1CB可能是人类BC的新的治疗靶点和诊断生物标志物。
Circular RNA (circRNA) is a newly discovered endogenous non-coding RNA (ncRNA), which is characterized with a closed circular structure. A growing body of evidence has verified the vital roles of circRNAs in human cancer. In this research, we selected circPPP1CB as a study object by circRNA sequencing and quantitative real-time PCR (qRT-PCR) validation in human bladder cancer (BC). CircPPP1CB is downregulated in BC and is negatively correlated with clinical stages and histological grades. Functionally, circPPP1CB modulated cell growth, metastasis, and epithelial-to-mesenchymal transition (EMT) process in vitro and in vivo. Mechanically, we performed various experiments to verify the circPPP1CB/miR-1307-3p/SMG1 regulatory axis. Taken together, our results demonstrated that circPPP1CB participates in tumor growth, metastasis, and EMT process by interacting with the miR-1307-3p/SMG1 axis, and that circPPP1CB might be a novel therapeutic target and diagnostic biomarker in human BC.
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