The future of blood-based biomarkers for Alzheimer's disease.
The future of blood-based biomarkers for Alzheimer's disease.
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DOI：
10.1016/j.jalz.2013.01.013
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发表时间：
2014-01
期刊：
影响因子：
--
通讯作者：
Blood-Based Biomarker Interest Group
中科院分区：
文献类型：
--
作者：
Henriksen K;O'Bryant SE;Hampel H;Trojanowski JQ;Montine TJ;Jeromin A;Blennow K;Lönneborg A;Wyss-Coray T;Soares H;Bazenet C;Sjögren M;Hu W;Lovestone S;Karsdal MA;Weiner MW;Blood-Based Biomarker Interest Group
Treatment of Alzheimer’s disease (AD) is significantly hampered by the lack of easily accessible biomarkers that can detect disease presence and predict disease risk reliably. Fluid biomarkers of AD currently provide indications of disease stage; however, they are not robust predictors of disease progression or treatment response, and most are measured in cerebrospinal fluid, which limits their applicability. With these aspects in mind, the aim of this article is to underscore the concerted efforts of the Blood-Based Biomarker Interest Group, an international working group of experts in the field. The points addressed include: (1) the major challenges in the development of blood-based biomarkers of AD, including patient heterogeneity, inclusion of the “right” control population, and the blood– brain barrier; (2) the need for a clear definition of the purpose of the individual markers (e.g., prognostic, diagnostic, or monitoring therapeutic efficacy); (3) a critical evaluation of the ongoing biomarker approaches; and (4) highlighting the need for standardization of preanalytical variables and analytical methodologies used by the field.
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DOI：
10.1016/s0140-6736(20)32205-4
发表时间：
2021-04-24
期刊：
Lancet (London, England)
影响因子：
--
作者：
Scheltens P;De Strooper B;Kivipelto M;Holstege H;Chételat G;Teunissen CE;Cummings J;van der Flier WM
通讯作者：
van der Flier WM
影响因子：
3.7
作者：
Chen, Yi-Song;Lim, Suh-Ciuan;Chen, Mei-Hsuan;Quinlan, Roy A.;Perng, Ming-Der
通讯作者：
Perng, Ming-Der
影响因子：
3.1
作者：
Bielewicz, Joanna;Kurzepa, Jacek;Bartosik-Psujek, Halina
通讯作者：
Bartosik-Psujek, Halina
影响因子：
5.3
作者：
Buerger, Katharina;Uspenskaya, Olga;Hampel, Harald
通讯作者：
Hampel, Harald
影响因子：
48
作者：
Barnes, Deborah E.;Yaffe, Kristine
通讯作者：
Yaffe, Kristine