Donut-like organization of inhibition underlies categorical neural responses in the midbrain.
Donut-like organization of inhibition underlies categorical neural responses in the midbrain.
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甜甜圈样的抑制组织是中脑分类神经反应的基础。
DOI：
10.1038/s41467-022-29318-0
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发表时间：
2022-03-30
影响因子：
16.6
通讯作者：
Mysore SP
中科院分区：
文献类型：
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作者：
Mahajan NR;Mysore SP
分类神经反应是各种形式的选择和决策的基础。这种类似二进制的响应在存在输入模糊性和神经噪声的情况下促进赢家的鲁棒信号发送。在这里，我们表明，一个“甜甜圈”的抑制机制，其中每个竞争选项抑制所有选项，除了自己，是非常有效的产生分类神经反应。它超越了决策模型中经常调用的反馈抑制、反复激发和分裂规范化的主题。我们的实验表明，这种机制不仅在谷仓猫头鹰的中脑空间选择网络，但它也是必要的分类信号由it.The功能模式的神经抑制在中脑形成一个结构精美的“多孔”甜甜圈一致的网络的组合抑制功能的刺激选择。此外，建模揭示了一个概括的神经实现的甜甜圈样图案的分类选择。因此，自我保留抑制可能是一个强大的电路模块分类的核心。分类神经元反应促进了决策，尽管输入噪声，它仍然稳健地发出赢家的信号。在这项研究中，作者证明了甜甜圈样抑制基序有效地产生了这种分类反应。
Categorical neural responses underlie various forms of selection and decision-making. Such binary-like responses promote robust signaling of the winner in the presence of input ambiguity and neural noise. Here, we show that a ‘donut-like’ inhibitory mechanism in which each competing option suppresses all options except itself, is highly effective at generating categorical neural responses. It surpasses motifs of feedback inhibition, recurrent excitation, and divisive normalization invoked frequently in decision-making models. We demonstrate experimentally not only that this mechanism operates in the midbrain spatial selection network in barn owls, but also that it is necessary for categorical signaling by it. The functional pattern of neural inhibition in the midbrain forms an exquisitely structured ‘multi-holed’ donut consistent with this network’s combinatorial inhibitory function for stimulus selection. Additionally, modeling reveals a generalizable neural implementation of the donut-like motif for categorical selection. Self-sparing inhibition may, therefore, be a powerful circuit module central to categorization. Decision making is facilitated by categorical neuronal responses, which robustly signal a winner despite input noise. In this study, the authors demonstrate that a donut-like inhibition motif effectively generates such categorical responses.
影响因子：
3.3
作者：
Jones HE;Andolina IM;Grieve KL;Wang W;Salt TE;Cudeiro J;Sillito AM
通讯作者：
Sillito AM