Targeted resequencing reveals genomic signatures of barley domestication.
Targeted resequencing reveals genomic signatures of barley domestication.
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DOI：
10.1111/nph.15077
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发表时间：
2018-05
期刊：
影响因子：
--
通讯作者：
von Korff M
中科院分区：
文献类型：
--
作者：
Pankin A;Altmüller J;Becker C;von Korff M
大麦（Hordeum vulgare）是研究新月沃地谷物驯化的既定模型。最近的分子数据表明，驯化大麦基因组由多个野生大麦种群的祖先区块组成。然而，马赛克祖先模式与驯化过程本身之间的关系仍不清楚。为了解决这一知识差距，我们基于 433 个野生和驯化大麦材料的定向重测序，使用选择扫描确定了候选驯化基因。我们进行了系统发育、种群结构和祖先分析，以分别在中性和候选驯化位点处调查驯化大麦单倍型的起源。我们发现在几个祖先野生种群背景下的驯化过程中，所有大麦染色体上都发生了多次选择性扫描。祖先分析表明，虽然驯化大麦基因组的祖先区块来自新月沃地各地，但候选驯化位点特别起源于其东部和西部地区。这些发现提供了第一个分子证据，表明在农业起源的黎凡特和扎格罗斯集群开始的大麦驯化过程中存在多种野生或原始驯化谱系。
Barley (Hordeum vulgare) is an established model to study domestication of the Fertile Crescent cereals. Recent molecular data suggested that domesticated barley genomes consist of the ancestral blocks descending from multiple wild barley populations. However, the relationship between the mosaic ancestry patterns and the process of domestication itself remained unclear. To address this knowledge gap, we identified candidate domestication genes using selection scans based on targeted resequencing of 433 wild and domesticated barley accessions. We conducted phylogenetic, population structure, and ancestry analyses to investigate the origin of the domesticated barley haplotypes separately at the neutral and candidate domestication loci. We discovered multiple selective sweeps that occurred on all barley chromosomes during domestication in the background of several ancestral wild populations. The ancestry analyses demonstrated that, although the ancestral blocks of the domesticated barley genomes were descended from all over the Fertile Crescent, the candidate domestication loci originated specifically in its eastern and western parts. These findings provided the first molecular evidence implicating multiple wild or protodomesticated lineages in the process of barley domestication initiated in the Levantine and Zagros clusters of the origin of agriculture.
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