Plasma nitrate as an index of nitric oxide formation in patients with acute infectious diseases.
Plasma nitrate as an index of nitric oxide formation in patients with acute infectious diseases.
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血浆硝酸盐作为急性传染病患者一氧化氮形成的指标。
DOI：
10.1080/00365549950163879
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发表时间：
1999
影响因子：
--
通讯作者：
T. Sandberg
中科院分区：
文献类型：
--
作者：
C. Åhrén;L. Jungersten;T. Sandberg
在人类中，一氧化氮（NO）在宿主防御中的作用是有争议的。我们前瞻性地研究了43例控制饮食中硝酸盐/亚硝酸盐的患者在急性感染期间血浆硝酸盐水平，硝酸盐是NO形成的稳定终产物。在急性胃肠炎期间，与4-5周后恢复期相比，平均血浆硝酸盐水平显著升高（118对32.5 μ mol/l; p < 0.001），与急性肺炎（PN; 34.6对42.8 μ mol/l）或发热性尿路感染（UTI; 27.7对31.3 μ mol/l）患者的结果相反。在第二组20例回顾性研究的严重PN或UTI患者中，其中70%为菌血症，在感染的急性期，硝酸盐水平没有显著增加。这些研究结果表明，增加NO生产，血浆硝酸盐，是不是一个普遍的发现，在急性感染性疾病患者，但可能与某些病原体或感染部位。
In humans, the role of nitric oxide (NO) in host defence is controversial. We prospectively studied plasma levels of nitrate, the stable end-product of NO formation, during acute infection in 43 patients controlled with regard to dietary nitrate/nitrite. During acute gastroenteritis the mean plasma nitrate level was significantly increased compared with at recovery 4-5 weeks later (118 vs. 32.5 micromol/l; p < 0.001), in contrast with the findings in patients with acute pneumonia (PN; 34.6 vs. 42.8 micromol/l) or febrile urinary tract infection (UTI; 27.7 vs. 31.3 micromol/l). In a second group of 20 retrospectively studied patients with severe PN or UTI, of whom 70% were bacteraemic, no significantly increased nitrate levels could be demonstrated during the acute stage of infection. These findings indicate that increased NO production, as measured by plasma nitrate, is not a general finding in patients with acute infectious diseases, but may rather be associated with certain pathogens or sites of infection.
影响因子：
11.8
作者：
DEGROOTE, MA;FANG, FC
通讯作者：
FANG, FC